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《Journal of First Military Medical University》 2003-10
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Mechanism of quercetin as an antidiarrheal agent

ZHANG Wen-ju, CHEN Bao-tian, WANG Cai-yun, ZHU Quan-hong, MO Zhi-xian Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China  
Objective To investigate the antidiarrheal mechanism of quercetin extracted from Psidium guajava L. Methods The effects of quercetin on the contractility of guinea pig ileum in vitro and on the peristaltic motion of mouse small intestine in vivo were observed, and the peak value of contractility and peristaltic distance recorded. The inhibitory effect of quercetin on the permeability of the abdominal capillaries was also observed. Results Quercetin inhibited the contraction of guinea pig ileum in vitro and the peristaltic motion of mouse small intestine, and reduced the permeability of abdominal capillaries. Conclusion Quercetin can inhibit the intestinal movement and reduce capillary permeability in the abdominal cavity, which may be the antidiarrheal mechanism of Psidium guajava L extract.
【Fund】: 国家自然科学基金(39970912);; 广东省中医药管理局资助课题(970241)~~
【CateGory Index】: R285
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