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《Journal of First Military Medical University》 2003-12
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Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by advanced glycation end-products in vitro

OUYANG Ping1, BEI Wei-jian2, LAI Wen-yan1, XU Ding-li1, PENG Wen-lie21Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China; 2Department of Biochemistry, School of Life Sciences, Sun Yat-sun University, Guangzhou 510275, China  
Objective ToobservetheeffectsofflavonefromtheleavesofDiospyros kaki onproliferationofadventitialfibroblasts induced by advanced glycation end-products (AGEs) in vitro. Methods NIH/3T3 cells cultured in vitro were treatedwith both AGEs and flavone from the leaves of Diospyros Kaki for observation in comparison with the cells that receivedtreatments with either AGEs or flavone, or neither. The ratio of cell proliferation was determined by non-radioactive MTS/PESassay. Results The ratio of cell proliferation was 0.840±0.061 in the untreated control group, and was 1.330±0.055, 1.210±0.119, 1.029±0.076 and 0.792±0.060 in AGEs groups corresponding to AGE concentrations of 100, 50, 10 and 1 μg/mlrespectively. AGEs significantly induced fibroblast proliferation in a dose-dependent manner when the concentration wasabove 10 μg/ml (P0.05), as compared with the untreated control group. (P0.05). The ratio of cell proliferation was 0.829±0.056 in cells treated with flavone at the concentration of 50 μg/ml, which alone failed to affect fibroblast proliferation (P0.05).With AGEs stimulation, however, flavone from the leaves of Diospyros kaki significantly inhibited the proliferation of thefibroblasts (P0.05).Conclusion Flavone from the leaves of Diospyros kaki can significantly inhibit the proliferation ofadventitial fibroblasts stimulated by AGEs in vitro.
【Fund】: 广州市科技局科技攻关项目(JB00000448165)~~
【CateGory Index】: R96
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【References】
Chinese Journal Full-text Database 5 Hits
1 Bei Wei-jian1,Li Chu-yuan2,Wang De-qin2,et al.(1.Guangzhou Pharmaceutical University,the Institute of Chinese Medicinal Sciences,Guangzhou,510006,P.R.China;2.Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine LTD,389 Shatai Road N.,Guangzhou,510515,P.R.China);Neuroprotective Effect of Flavonoid from the Leaves of Diospyros Kaki on Acute Forebrain Ischemia Reperfusion Injury in Rats[J];Guangxi Journal of Traditional Chinese Medicine;2009-02
2 Lin Jiaofen~1 Lin Hetong~1,2 Xie Lianhui~2Lin Qiying~2 Chen Shaojun~1 Zhao Yunfeng~11(College of Food Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China) 2(Key Laboratory of Bio-pesticide and Chemical Biology, Ministry of Education, P. R. China, Fujian Agriculture and Forestry University, Fuzhou, 350002, China);A Review of Chemical Constituents, Medicinal Function, Clinical Application of Persimmon Leaves and Their Development and Utilization[J];Food and Fermentation Industries;2005-07
3 SU Dong-hai,WU Qiong,HE Shu-fang,SUN Jun-she(College of Food Science and Nutritional Engineering, China Agricultural University,Beijing 100083, China );Study on Extraction Technology of Flavones from Diospyros kakl Leaves[J];Food Science;2005-S1
4 ZHENG Hao1,LU Zhou-min1,LIU Yue-mei1,BAI Wei-dong2 (1 College of Forestry,Northwest A & F University,Yangling,Shaanxi 712100,China;2 College of Light Industry and Food,Zhongkai College of Agriculture and Technology,Guangzhou,Guangdong 510225,China);Review of medicinal function of persimmon leaves and their development and utilization[J];Journal of Northwest A & F University(Natural Science Edition);2007-12
5 Ouyang Ping~1, Bei Weijian~2, Lai Wenyan~1, Peng Wenlie~2 (1.Nanfang Hospital, First Military Medical University, Guangzhou 510515; 2.Department of Biochemistry, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275);Effects of Flavone from Leaves of Diospyros kaki on Rat Vascular Smooth Muscle Cells Proliferation Stimulated by Native Low-density Lipoprotein in Vitro[J];Journal of Chinese Medicinal Materials;2004-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 FENG Guo-xuan (The School of Biological Science and Technology of Hubei Institute for Nationalities, Enshi, Hubei 445000);Research on Domesticating Thladian henryi Convenient to Edibles and Medicaments[J];Journal of Anhui Agricultural Sciences;2005-07
2 ZOU Sheng-qin et al (Provincial Key Laboratory of Research on Active Ingredients in Natural Medicine,Bioengineering Research Institute of Yichun University,Yichun,Jiangxi 336000);Research Advances in Sumbucus Chinensis Lindl.[J];Journal of Anhui Agricultural Sciences;2006-13
3 FENG Guo-xuan (Horticulture Department of Bioscience and Technical Collge,Hubei Institute for Nationalities,Enshi,Hubei 445000);Study of Biology Characteristic Property and Domestication on Cynanchum auriculatum Royle ex Wight[J];Journal of Anhui Agricultural Sciences;2007-35
4 DING Ping et al (Lianyungang Chinese Medicine Branch of Jiangsu United Vocational College,Lianyungang,Jiangsu 222006);Study Progress on the Chinese Herb Salvia plebeia R.Br.[J];Journal of Anhui Agricultural Sciences;2008-10
5 CAO Jie-wei(Shangqiu Center of Animal Disease Control,Shangqiu,Henan 476000);Pharmacological Test Study on Analgesic and Anti-inflammatory Effect of Gracilaria lemaneiformis[J];Journal of Anhui Agricultural Sciences;2009-16
6 TIAN Chun-yuan (School of Life Science and Technology,Xiaogan University,Xiaogan,Hubei 432000);Herbal Textual Research on Huihuidou(Semen Ciceris Arietini.)[J];Journal of Anhui Agricultural Sciences;2009-21
7 TAN Ying-chun,LI Ke-qin,XU Hong-yan,MA Jian-feng(Shandong University,Shandong provincial Hospital,Shandong Ji′nan 250021,China);Experimental Study on Treating Primary Dysmenorrhea with Tongjing Mixtures[J];Journal of Anhui Traditional Chinese Medical College;2006-01
8 HU Zheng, LI Hua-ping, YE Mao-qing, YU Huai-dong, ZOU Guo-lin* (1. College of Life Science,Wuhan University,Wuhan 430072,China; 2.College of Life Science,Hubei Industry University ,Wuhan 430072,China);Investigation Advance in Pharmacological Activity of Cordyceps sinensis[J];Amino Acids & Biotic Resources;2003-04
9 Wu Xiaoning1,Xiong Yaokang2 Zhejiang Medical College,Hangzhou(310053),China;Study on Processing Technology of Tremella Polysaccharide Capsule[J];Journal of Zhejiang University of Traditional Chinese Medicine;2008-04
10 Wang Juan; Du Fan; Ma Qinyan; Chen Xialin. Southwest Forestry College, Kunming, 650224, P.R.China.;Medicinal plant resources and their diversity in Mountain Dawei National Nature Reserve in Yunnan, China.[J];Journal of Beijing Forestry University;2002-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Chuan-hu~1, ZHENG Gui-fu~2(1.Department of Chemistry, Bengbu Education College, Bengbu 233050, China;2. Department of Food Engineering, Bengbu College, Bengbu 233030, China);Technological Study about Producing Peach Fruit Vinegar[J];Journal of Anhui Technical Teachers College;2004-04
2 JIANG Su,MENG Hua-zhen,HE Yan-fang(Guangxi Guilin Agricultural School, Guilin 541006, China);Study on Technology of Fermented Persimmon Wine[J];Storage and Process;2004-04
3 LIN Jiao- fen1,LIN He- tong1,2,CHEN Shao- jun1,ZHAO Yun- feng1,WENG Hong- li 1,CHEN Lian1 (1. College of Food Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002,China; 2. Key Laboratory of Bio?- pesticide and Chemical Biology, Ministry of Education, China, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002,China);Effects of Fixing Technology on Organoleptic Qualities of Green Persimmon Leaves′ Tea[J];Packaging and Food Machinery;2005-03
4 ZHANG Bin~* LIU Zhen-hua OUYANG Ping~* CHEN Ye~* LAI Wen-yan~* XU Ding-li~*.~*Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Effect of tumor necrosis factor-α on proliferation of in vitro cultured rat VSMC and expression of syndecan-4 protein[J];Chinese Journal of Neuromedicine;2007-07
5 Liu Zhili,Xu Yuefei,Tu Caixia,et al [WT5BX]Department of Dermatology,the First Affiliated Hospital,Dalian Medical University,Dalian,China [WT5HZ];Studies on the effect of ethanol extracts of 56 traditional Chinese drugs on the activity of tyrosinase[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;2000-01
6 CAO Wei-guo~(1,2),LIU Zhi-qin~1,SHAO Yun~1,TAO Yan-duo~*(1 Northwest Institute of Plateau Biology, Chinese Academy of Sciences ,Xining 810001,China;2 Graduate School of the Chinese Academy of Sciences,Beijing 100031,China);A progress in pharmacological research of flavonoids[J];Acta Botanica Boreali-occidentalia Sinica;2003-12
7 DING Guo Bin, CHEN Bi, TANG Chao Wu Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Effects of arbutin on cultured human melanocytes[J];Journal of The Fourth Military Medical University;2001-20
8 ZENG Ping, XU Ding-li, LI Zhen, LAI Wen-yan, REN Hao Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Effects of advanced glycation end-products on cell cycle distribution and apoptosis in neonatal rat cardiac myocytes[J];Journal of First Military Medical University;2003-01
9 OUYANG Ping 1 , BEI Wei-jian 2 , LAI Wen-yan 1 , XU Ding-li 1 , PENG Wen-lie 21 Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China; 2 De-partment of Biochemistry, School of Life Sciences, Sun Yet-sun University, Guangzhou 510275, China;In vitro effects of flavone from leaves of Diospyros kaki on rat cardiac myocyte apoptosis in-duced by hypoxia-reoxygenation and advanced glycation end products[J];Journal of First Military Medical University;2003-07
10 OUYANG Ping 1 , MENG Su-rong 1 , LIU Yan-bo 1 , XU Ding-li 1 , LAI Wen-yan 1 , PENG Li-sheng 2 , XU An-long 2 1 Department of Cardiology, Nanfang Hospital, First Military Medical Universit y, Guangzhou 510515, China; 2 Depart-ment of Biochemistry, School of Life Science, Sun Yat-sen University, Guangzhou 510275, China;Effects of recombinant human interleukin-10on tumor necorsis factor-α-induced adventitial fibroblast proliferation in vitro[J];Journal of First Military Medical University;2004-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LIN Da-cai 1,3,WU Si-fu 2,LIN He-tong 3,LIN Jiao-fen3,ZHANG Bing-ling4(1.Anxi Soil and Water Conservation Office of Fujian Province,Anxi,Fujian 362400,China; 2.Anxi Institute of Agricultural Sciences of Fujian Province,Anxi,Fujian 362400,China; 3.College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);Processing Technology of 'Anxi persimmon leaves' Health Tea[J];Packaging and Food Machinery;2006-04
2 WU Yu-lin1,3,LIN Jiao-fen1,2,LIN He-tong1,CHEN Lian1,CHEN Yi-hui1(1.College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China; 2.Department of Biology,Zhangzhou Normal University,Zhangzhou Fujian 363000,China; 3.Agriculture,Tea and Fruit Bureau of Anxi County in Fujian Province,Anxi Fujian 362400,China);Effects of Harvesting Dates on Chemical Constituents of An'xi Persimmon Leaves[J];Packaging and Food Machinery;2007-06
3 KE Fan-sheng1,LIN Jiao-fen1、2,LIN He-tong1(1. College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China;2. Department of Biology, Zhangzhou Normal University, Zhangzhou Fujian 363000, China);Analysis and Evaluation of Nutritional Components of ‘Anxi’ Persimmon Leaves[J];Packaging and Food Machinery;2009-01
4 LIN Jiao-fen~(1,2),LIN He-tong~2,CHEN Shao-jun~2,LIU Mu-shui~2,CHEN Lian~2(1.Department of Biological Science and Biotechnology,Zhangzhou Normal University,Zhangzhou,Fujian 363000,China;2.College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);Effects of withering technology by natural spreading on improving quality of persimmon leaf tea[J];Journal of Fujian Agriculture and Forestry University(Natural Science Edition);2007-01
5 LUO Zhi-gang,ZHAO Xi-hong~*,HE Xiao-wei(College of Light Industry and Food Science in South China University of Technology,Guangzhou 510640,China);Study on the ethanol extraction conditions and anti-oxidation property of flavonoids from leaves of Diospyros kaki[J];Guangdong Agricultural Sciences;2006-12
6 CHEN Che1,CHU Hui-yuan1,YANG Ya-li1,WANG Ya-li1,DONG Jian-yong2(1.Center of Science and Research,Gansu College of Traditional Chinese Medicine,Lanzhou 730000,China;2.School of Pharmacology,Wenzhou Medical College,Wenzhou 325035,China);Protective Effect of Total Flavonoids of Hedysarum Polybotry on Human Umbilical Vein Endothelial Cells Injury Treated by High Glucose[J];Journal of Gansu Sciences;2007-02
7 LIN Min1,2,QIU Ling1,ZHONG Xue1,SHI Yan1,CHEN Qing-xi1(1 School of Life Sciences,Xiamen University,Xiamen 361005,China;2 School of Life Sciences,Longyan University,Longyan 364000,China);Inhibitory effect of extract of persimmon leaf on potato polyphenol oxidase(PPO)[J];Journal of Guangxi Agricultural and Biological Science;2008-04
8 Luo Yulan,Ma Jiejin,He Ming,et al.(Department of Pharmacology,Guangxi Medical University,Nanning 530021 China);EFFECTS OF KETANGTE ON BLOOD SUGAR IN ANIMAL MODELS OF DIABETES MELLITUS[J];Journal of Guangxi Medical University;2008-02
9 WANG Ning1,LI Yuan-zhi2,XU Li-zhen2,NAN Ji2 (1.Beijing Jiafude Food Co. Ltd.,Beijing 100300,China) (2.College of Food Science,South China Agriculture University,Guangzhou,510642,China);Research on Ultrasonic Extraction of Flavone from Persimmon Leaves[J];Modern Food Science and Technology;2008-07
10 SHEN Hong-xia et al(Huanggang Polytechnic College,Huanggang,Hubei 438002);Study Status of Persimmon Resources[J];Journal of Anhui Agricultural Sciences;2009-23
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