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《Journal of First Military Medical University》 2003-12
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Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by advanced glycation end-products in vitro

OUYANG Ping1, BEI Wei-jian2, LAI Wen-yan1, XU Ding-li1, PENG Wen-lie21Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China; 2Department of Biochemistry, School of Life Sciences, Sun Yat-sun University, Guangzhou 510275, China  
Objective ToobservetheeffectsofflavonefromtheleavesofDiospyros kaki onproliferationofadventitialfibroblasts induced by advanced glycation end-products (AGEs) in vitro. Methods NIH/3T3 cells cultured in vitro were treatedwith both AGEs and flavone from the leaves of Diospyros Kaki for observation in comparison with the cells that receivedtreatments with either AGEs or flavone, or neither. The ratio of cell proliferation was determined by non-radioactive MTS/PESassay. Results The ratio of cell proliferation was 0.840±0.061 in the untreated control group, and was 1.330±0.055, 1.210±0.119, 1.029±0.076 and 0.792±0.060 in AGEs groups corresponding to AGE concentrations of 100, 50, 10 and 1 μg/mlrespectively. AGEs significantly induced fibroblast proliferation in a dose-dependent manner when the concentration wasabove 10 μg/ml (P0.05), as compared with the untreated control group. (P0.05). The ratio of cell proliferation was 0.829±0.056 in cells treated with flavone at the concentration of 50 μg/ml, which alone failed to affect fibroblast proliferation (P0.05).With AGEs stimulation, however, flavone from the leaves of Diospyros kaki significantly inhibited the proliferation of thefibroblasts (P0.05).Conclusion Flavone from the leaves of Diospyros kaki can significantly inhibit the proliferation ofadventitial fibroblasts stimulated by AGEs in vitro.
【Fund】: 广州市科技局科技攻关项目(JB00000448165)~~
【CateGory Index】: R96
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