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《Journal of First Military Medical University》 2004-01
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Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type1

SUN Yan, YANG Jie Department of Pharmaceutics, General Hospita l of PLA, Beijing 100853, China  
Objective To study the inhibitory eff ec ts of Astragalus membranaceus on herpes simplex virus type 1(HSV-1). Methods In the 2BS cells infected with HSV-1, the antiviral effect of Astragalus membranac eus decoction was investigated by observing the inhibition of HSV-1-induced cyt opathic effect in response to treatment with the decoction. Results The half in hibition concentration (IC50) and minimal inhibition concentration (MIC) of Astr agalus membranaceus were 0.98 and 1.95 μg/ml respectively, with the therapeutic index (TI) of 128. Conclusion Astragalus membranaceus has obvious HSV-1-inhibit -ing efficacy and low cytotoxicity.
【CateGory Index】: R285
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