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《Journal of First Military Medical University》 2004-03
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Preparation of drug-loaded polylactic acid nanospheres and drug-releasing performance evaluation

LI Liang1, LI Guo-ming2, HUANG Wei-hua11Nanchang Municipal Health and Anti-Epidemic Station, Nanchang 330006, China; 2Department of Chemistry, South China Normal University, Guangzhou 510631, China  
The polylactic acid (PLA) nanospheres containing griseofulvin were prepared by a water-in-oil solvent evaporation method adopting an uniformly designed experiment, and the drug-releasing rates were compared between the microsphere and nanosphere. The results showed that the nanospheres was good in spherical shape with narrow distribution of the particle sizes. The particle diameter was about 114 nm, and the comprehensive score of the nanosphere was 95.59, with the error of 3.66% and the drug content of 13.55% by the linearity regression averaged from the results of the three repeat experiments. The drug-releasing rate of the microsphere was relatively slow, while that of the nanosphere can have an abrupt increase, indicating its function of solubilizing the drug.
【CateGory Index】: TQ460
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