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《Journal of First Military Medical University》 2004-06
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Biocompatibility evaluation of chitosan-g-polyvinylpyrrolidone

DENG Zheng-xing, ZHANG Zhi-xiong, LI Li-hua, ZHOU Chang-ren College of Life Science and Technology, Jinan University, Guangzhou 510632, China  
Objective To evaluate the biocompatibility of chitosan-g-polyvinylpyrrolidone as a new scaffold material. Methods The material was tested and measured for water absorption and contact angle, followed by evaluation of the biocompatibility by implantation into rabbits and in vitro cultured with the corneal epithelial cells. Results The water absorption rate of the material reached 1 100% with contact angle of 83°-86°. The results of implantation revealed partial degradation of the material 3 months after implantation, and much collagen and numerous corneal stromal cells appeared on the material without obvious inflammation reactions. In vitro coculture with epithelial cells showed good adhesion of the cells to the material which induced no obvious cytotoxicity. Conclusion The novel chitosan derivative has excellent biocompatibility and can be used as a tissue scaffold material.
【Fund】: 国家自然科学基金(30170272);; 国家科技部重大基础研究项目(973项目)子课题(G199054306);; 国家科技部高技术计划项目(863)(2001AA625050)~~
【CateGory Index】: R318.08
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