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《Journal of First Military Medical University》 2004-11
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Prevalence of hemorrhagic fever with renal syndrome virus in domestic pigs: an epidemiological investigation in Shandong province

YANG Zhan-qing1, YU Shou-yi1, NIE Jun1, CHEN Qing1, LI Zhi-feng1, LIU Yun-xi2, ZHANG Jin-lan2, XU Jian-jiang2, YU Xiao-ming2, BU Xiu-ping2, SU Jing-jing2, ZHANG Yun3, TAO Kai-hua31Department of Epidemiology, Southern Medical University, Guangzhou 510515, China; 2Institute of Military Medicine of Jinan Command, Jinan 250014, China; 3Institute of Military Medicine of Nanjing Command, Nanjing 210002, China  
Objective To investigate the epidemiological significance of hemorrhagic fever with renal syndrome virus (HFRSV) infection in domestic pigs in Shandong province, and study the role of domestic pigs in the prevalence of HFRS. Methods Epidemiological investigation was performed in 4 cities of Shandong province. Reversed passive hemagglutination assay (RPHA), reversed passive hemagglutination inhibition (RPHI), HPR-SPA, immunofluorescent antibody (IFA), and reverse transcriptional PCR (RT-PCR) were used to detect antigen and antibody of HFRSV. Results HFRSV antigen and antibody were detected in the heart, liver, lung, spleen, kidney, blood, urine, and stool of domestic pigs as well as in the sewage of the pigpen facilities. The positivity rate of HFRSV antigen ranged from 3.33% to 5.00% in the organ of pigs, and HFRSV positivity rate in the blood, urine, stool, and sewage was 3.67%, 7.04%, 2.51%, and 5.56%, respectively, with a total serum antibody positivity rate of 1.96%. The virus was isolated from the HFRSV antigen-positive samples, and could infect many organs after artificial infection of the pigs. HFRSV antigen can be detected in suckling rat brain and histopa- thological exanimation suggested transient pathological changes in such organs as the liver, lung and kidney. HFRSV may proliferate in pigs and was discharged through multiple routes. Conclusion Domestic pigs can be the host of HFRSV for the viral transmission.
【CateGory Index】: S858.28
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