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Expression of peroxisome proliferator-activated receptor γ in glioma

WANG Ming-hua1, ZHONG Xue-yun2, LIN Chen-li2, XIE You-ke2, JIA Jin-ping2, LI Su-mei2, MI Can11Department of Pathology, Chongqing Medical Oniversity, Chongqing 410016, China; 2Department of Pathology, Meaical college of Ji'man University, Gnangzhou 510632, China  
Objective To investigate the expression and significance of peroxisome proliferators-activated receptor γ (PPAR γ) in human glioma. Methods Immunohistochemical staining for PPARγ was performed using biopsy specimens of human glioma of various histological types. Expression of PPAR γ and GFAP in glioma cell lines SWO-38, U251 and SHG-44 were analyzed using Western blotting and reverse transcription-polymerase chain reaction ( RT-PCR). Results Immunohistochemical study showed that PPARγ was expressed in glioma tissues with positive rate of 37.5%. Western blotting and RT-PCR showed that PPARγ was expressed in both glioma cell lines SWO-38 and U251, but not in SHG-44 cells. However, high expression of GFAP was detected in SHG-44 cells. Conclusion PPARγ is associated with carcinogens of glioma. Actived PPARγ by agonist may be a novel approach to the treatment of glioma.
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