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Effects of lipopolysaccharides of Becterium prodigiosum on tumor growth and immunosuppression in mice

YU Chuan-lin,ZHU Zheng-guang,LEI Lin-sheng,CHANG Hua-lei,GAO Hui-ling,CHEN Na-na,YANG Xian-guo Drug Research Institute,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China  
Objective To observe the effects of lipopolysaccharides of Bacterium prodigiosum(BP-LPS) in inhibiting tumor growth and improving immunosuppression in mice.Methods In mice bearing S180 tumor and a mouse model of immunosuppression induced by cyclophosphamide(CTX),the tumor growth,indexes of the immune organs and peripheral white blood cell count were measured after intraperitoneal injection of BP-LPS.Results Injections of BP-LPS(40 U/kg) for 8 consecutive days resulted in a significant inhibition of the tumor growth in mice bearing S180 tumor(P0.01),with a dose-dependent increase of the spleen indexes but no obvious changes in the thymus indexes.Intraperitoneal injections of BP-LPS for 7 days inhibited the reduction of peripheral white blood cells and spleen indexes in immunosuppressive mice,but did not produce any significant changes in normal mice.Conclusion BP-LPS can inhibit the tumor growth in tumor-bearing mice and enhance the immune functions of immunosuppressive mice.
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