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《Journal of Southern Medical University》 2009-11
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Clinical significance of detecting serum erythropoietin in patients with leukemia

SU Na,LIU Jin Department of Hematology,Shenzhen Hospital of Peking University,Shenzhen 518036,China  
Objective To detect serum erythropoietin(EPO) levels in patients with acute leukemia(AL) and iron deficient anemia(IDA) with moderate or severe anemia and explore the mechanism of anemia in these patients.Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect the serum levels of EPO in 59 patients with AL,among whom 15 had complete remission without anemia and 44 had moderate or severe anemia(including 12 receiving the initial treatment,13 with complete remission and concurrent anemia,and 19 with bone marrow suppression).Serum EPO was also detected in 15 IDA patients and 12 healthy individuals.Results The IDA patients and healthy individuals had similar serum EPO levels(P0.05),and by comparison,the EPO levels were significantly increased in AL patients upon the initial treatment,those with bone marrow suppression and those with complete remission and anemia,but comparable between the latter 3 groups(P0.05).Among the patients with complete remission,the EPO levels were significantly higher in anemic patients than in those without anemia(P0.05),and the latter patients had similar EPO levels with the healthy individuals(P0.05).In both AL and IDA patients with moderate or severe anemia,the serum EPO level was inversely correlated to the level of hemoglobin(r=-0.697 and-0.970,respectively,P0.05).Conclusion AL patients with anemia have significantly higher serum EPO levels than healthy individuals.In AL and IDA patients with moderate or severe anemia,EPO levels are inversely correlated to the level of hemoglobin,suggesting the integrity of the EPO synthesis mechanism in AL patients.Serum EPO level is also associated with bone marrow function in addition to hypoxia and hemoglobin levels,and hematopoiesis deficit in the early stage may be the main cause of anemia.
【CateGory Index】: R733.71
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Huan,WANG Zhao,LIU Jin-li(Dept of Hematology,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China);Clinical significance of serum erythropoietin in patients with hematologic malignancies[J];Journal of Shanxi Medical University;2007-08
2 HAN Bing~* SHI Yuan-kai ZHU Jun HE Xiao-hui LIN Ning-jing LI Shu-lan SHEN Ti. *Department of Hematology,Peking Union Medical College Hospital,Beijing 100730,China;Study on serum erythropoietin levels in patients with hematologic malignancies[J];Chinese Journal of Hematology;2006-08
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LIU Dong-Fang Department of Hematology,Tangshan People's Hospital,Tangshan 063000,China;Influence of tumor necrosis factor-α on erythropoietin production in patients with malignant hematological diseases[J];Journal of the Fourth Military Medical University;2009-20
2 XU Yong-mei, ZHOU Jian-feng, CHAI Jian-nong, ZHANG Min (Department of Pediatrics, The First Hospital of Changshu, Changshu 215500, Jiangsu, China);Aplastic anemia with normal reticulocyte:six cases report[J];Journal of Clinical Pediatrics;2009-10
3 WANG Huan,WANG Zhao,LIU Jin-li(Dept of Hematology,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China);Clinical significance of serum erythropoietin in patients with hematologic malignancies[J];Journal of Shanxi Medical University;2007-08
4 CHEN Ling-song, ZHANG Qiu-rong, CHEN Xing-guo, CAO Ruo-nan, SONG Wen-wei, ZHANG Gui-hua, XU Jin-ge (Department of Hematology, the Second Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221006, P.R.China);Study on serum erythropoietin levels in patients with hematopoietic system disease[J];China Journal of Modern Medicine;2008-19
5 YAO Xiao-wei.Department of Physiology,Hubei Traditional Chinese Medical College,Wuhan 430065,China;The relativity between erythropoietin and the degree of empyrosis and hemophthisis in burned rats[J];Chinese Journal of Modern Drug Application;2009-22
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 HAN Bing~* SHI Yuan-kai ZHU Jun HE Xiao-hui LIN Ning-jing LI Shu-lan SHEN Ti. *Department of Hematology,Peking Union Medical College Hospital,Beijing 100730,China;Study on serum erythropoietin levels in patients with hematologic malignancies[J];Chinese Journal of Hematology;2006-08
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