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《Journal of Southern Medical University》 2010-09
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Analgesic effect of Corydalis yanhusuo in a rat model of trigeminal neuropathic pain

HUANGJin-yu1,FANGMin2,LIYi-jing3,MA Yong-quan1,CAIXiao-hui1 1Department of Stomatology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;2Department of Stomatology,Central Hospital of Hami Region,Xinjiang 839000,China;3Oral Class of 2007,Medical College of Jinan University,Guangzhou 510632;China  
Objetive To evaluate the analgesic effect of Corydalis yanhusuo on trigeminal neuropathic pain.in a rat model.Method Ratmodel of trigeminal neuralgiapainwere establishedby inducing chronic constrictioninjury(CCI) of the infraorbital branchof the trigeminal nerve(ION).The effect of Corydalis yanhusuo,a traditional Chinese medicine,in ameliorating the pain was tested.Western blotting was performed to investigate the change of cannabinoid CB1 receptors in the Vc the injury of the infraorbital branchof the trigeminal nerve(ION-CCI).CB1 receptorantagonistAM251 was appliedto observe its effectonthe analgesic effectof Yanhusuo.Result Administrationof dl-THP(2 mg/kg) intraperitoneally increasedthe response thresholdand the cut-off threshold to the mechanical stimulation in ION-CCI rat models.ION-CCI induced an upregulation of cannabinoid CB1 receptors withinthe ipsilateral of Vc.The effectof Yanhusuo was antagonizedby the applicationof AM251.Conclusion The analgesic effect of Yanhusuo involves the participation of CB1 receptors,suggesting that Yanhusuo may offer a useful therapeutic approachfortrigeminal neuropathic pain.
【CateGory Index】: R745.11
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