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《Journal of Southern Medical University》 2011-10
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Bioequivalence of pyridostigmine bromide dispersible tablets in rabbits

WANG Hong1,TAN Qun-you2,ZHANG Li1,CHENG Xun-guan3,ZHANG Jing-qing1 1Medicine Engineering Research Center in University,3Research Lab of Medicinal Chemistry and Biological Material,Chongqing Key Laboratory of Biochemical&Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,China;2Department of Thoracic Surgery,Daping Hospital & Research Institute of Surgery,Third Military Medical University,Chongqing 400042,China  
Objective To compare the pharmacokinetic parameters of pyridostigmine bromide dispersible tablets and common tablets in rabbits.Methods Twelve rabbits were given an oral dose(60 mg) of pyridostigmine bromide dispersible tablets or common tablets in a randomized crossover study.The plasma concentration of pyridostigmine bromide was determined by reversed-phase ion pair chromatography.The pharmacokinetic parameters were calculated using DAS2.1.1 software.Results The pharmacokinetic parameters showed no significant differences in rabbit plasma between pyridostigmine bromide dispersible tablets and common tablets.The two tablets had a Cmax of 1.83±0.08 mg·L-1 and 1.68±0.03 mg·L-1,tmax of 2.33±0.41 h and 2.58±0.20 h,AUC0-24 of 15.50±0.62 mg·h·L-1 and 15.14±0.30 mg·h·L-1,AUC0-∞ of 15.82±0.70 mg·h·L-1 and 15.57±0.32 mg·h·L-1,respectively.The relative bioavailability F0-24 was 102.38% and F0-∞ was 101.61% for the dispersible tablets.Conclusion The two tablets are bioequivalent in rabbits.
【Fund】: 教育部博士点基金(20095503120008);; 重庆市教育委员会资助项目(KJ090308)
【CateGory Index】: R96
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