Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Southern Medical University》 2011-12
Add to Favorite Get Latest Update

Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis

HE Wei1,HU Zuo-jun1,XU An-wu2,YIN Heng-hui1,WANG Jin-song1,YE Jie-lian1,WANG Shen-ming1 1Department of Vascular Surgery,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;2Division of Nanomaterials and Chemistry,Hefei National Laboratory for Microscopic Physical Sciences,University of Science and Technology of China,Hefei 230026,China  
Objective To develop a small-caliber vascular grafts and study its morphologies,mechanical properties and biocompatibility.Methods The effects of electrospinning conditions on the microstructure and porosity of the resulting scaffolds were investigated for preparation of a small-caliber(4 mm) polyurethane vascular grafts with optimum microstructures and mechanical properties.The mechanical properties and biocompatibility of the prepared grafts were evaluated.Results The polyurethane vascular grafts showed a three-dimensional reticular structure consisting of nanofibers,with an average porosity of(51.48±4.47)% and tensile strength of 5.85 ± 0.62 MPa.The grafts provided a better long-term support than e-PTFE graft for endothelial cell growth and endothelialization.Conclusion The polyurethane vascular prosthesis possessed favorable microstructures,excellent mechanical properties and good biocompatibility for potential clinical application.
【Fund】: 国家“863”项目(2007AA021904);; 广东省科技计划项目(2011B031300002 2010B031600055)~~
【CateGory Index】: R654.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved