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《Journal of Southern Medical University》 2012-04
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Effects of mustard seed on 2,4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice

WEN Chunmiao1,YANG Runping1,HU Jian1,JIAO Zelong2,YANG Yuguang1,YANG Jianling3,LI Hengjin1,ZHAO Hua1 1Department of Dermatology,General Hospital of PLA,Beijing 100853,China;2Department of Dermatology,Clinic Affiliated to Navy Headquarter,Beijing 100039,China;3Department of Dermatology,513 Hospital of PLA,Lanzhou 732750,China  
Objective To investigate the therapeutic effect of mustard seed on allergic contact dermatitis(ACD) in mice and explore the mechanism.Methods Eighteen BALB/c mice were randomly divided into normal control group,model group and mustard seed group.The mice in the normal control group and model group were fed with normal chow,and those in mustard seed group were given 5% mustard seed mixed in the chow.Three weeks later,ACD was induced on the ear using 2,4-dinitrofluorobenzene.After 24 h,the swelling of the ear was examined,and the rats were sacrificed to collect the ear tissue ears and blood for histopathological and immunohistochemical examinations,RT-PCR and enzyme-linked immunosorbent assay.Results In mice with ACD,feeding with mustard seeds significantly lessened the ear swelling,improved the tissue histopathology,lowered the number of infiltrating Langerhans cells,and reduced the expressions of IL-1β,TNF-α and IL-6 mRNA in the ear,but did not cause significant changes in serum levels of IL-4,IFN-γ and IL-17.Conclusion Mustard seed inhibits ACD in mice possibly by suppressing the expressions of IL-1β,TNF-α and IL-6 mRNA and inhibiting Langerhans cell migration in the epidermis.
【Fund】: 解放军总医院苗圃基金(01020604)
【CateGory Index】: R285.5
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