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《Journal of Southern Medical University》 2013-07
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Dexmedetomidine improves oxygenation during one-lung ventilation in balanced anesthesia with propofol-fentanyl in adults

LAI Yong, LI Yalan, LIU Yuyong, PENG Xuemei, WANG Hao, ZOU Peng Department of Anesthesiology, First Affiliated Hospital of Ji'nan University, Guangzhou 510630, China  
Objective To investigate the effect of dexmedetomidine on oxygenation function in adult patients with balanced anesthesia by propofol- fentanyl under one- lung ventilation (OLV). Methods Twenty- two patients undergoing thoracic operation were randomly divided into the study group and control group, both receiving propofol and fentanyl balanced anesthesia. In the study group, additional infusion of dexmedetomidine (0.3 μg/kg loading dose, 0.3 μg. kg - 1 . h - 1 maintenance dose) was administered, and the patients in the control group received only normal saline. Arterial blood samples were obtained at 4 time points from each patient during anesthesia for blood gas analysis. Results In the study group, the pH values remained stable, the oxygenation index tended to decline progressively, but the incidence of hypoxemia was low; in the control group, the pH value and oxygenation index both declined progressively with a higher incidence of hypoxemia. Conclusion Dexmedetomidine can better maintain the oxygenation function of OLV patients in balanced anesthesia by propofol and fentanyl, and its mechanism may be related to the decreased dose of propofol used.
【CateGory Index】: R614
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