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《Progress In Veterinary Medicine》 2002-03
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The Residues and Detection of Clenbuterol

WANG Xuan nian 1, KANG Xiao di 2, PAN Yao qian 3, ZHAGN Gai ping 4 (1. Henan Vocational Technical Teachers College, Xinxiang, 453003,China; 2. Henan Baiao Biotechnology Co Ltd, Zhengzhou, 450002, China; 3. Quartermaster University of PLA, Chang  
Clenbuterol (CL) is a β 2 adrenergic agonist. Therapeutically, it is used in human and veterinary medicine as a borochodilator for treatment of respiratory conditions. CL can exhibit metabolic effects to promote muscle growth and decrease fat deposition when it was given in dosages 5 to 10 times higher than those required for therapeutic treatment. However, CL can remains in tissue of treated animal and cause symptoms of acute poisoning in people. No country has permitted CL as a growth promoting agent in farm animals. This review focuses on the metabolism, absorption and tissue residues of CL in food producing animals, and also describes the outbreak of food poisoning at home and abroad. FDA, WHO and our government have published the regulations of maximum residue limits (MRL) of CL. Biologically, the characteristics of CL employs, first of all, rapid and extensive absorption; secondly, the accumulation of CL in urine, lever, lung and kidney is dosage and time dependent; thirdly, the elimination of CL is biphasic pattern and more slowly. In detection of residues of CL, the combination of screening methods based on enzyme immunoassay and confirmatory methods of GC/MS should be used to cope with the illegal use of CL in farm animals.
【Fund】: 河南省重大攻关项目
【CateGory Index】: S859.84
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