Observation on the Poxvirus Infection in KM and BALB/c Mice
SHI Chang hong,LI Liu jin,LI Cheng,LI Hong (The labarotory Animal Research Center,Fourth Millitary Medical University,Xian,710032,China)
An outbreak of poxvirus infection was occurred in twenty bought KM and BALB/c mice .The livers,spleens, kidneys, lymph nodes and cerebrum of ill mice were used to histology observation. The characteristic of pathologic change was poxvirus infection .when the tissue homogenate fluid infected passaging BHK cell, we could see apparent CPE change. A lot of poxvirus particle were found in EMP. The center of particle was nucleoid composed by DNA and protein ,The agglutination reaction was positive (HA=1:16).By ELISA kit examination the serum of ill mice expressed poxvirus antibody positive reaction, After suspension of virus infected KM and BALB/c mice .It was found that the former was easily infected, with apparent symptom .The latter had strong resistance, latent infection. The symptom always occurred slowly, but when experiment factors were exerted,the BALB/c mice quickly had symptom, and died. It proved that the pathogen was poxvirus .
【CateGory Index】： S858.91