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Research Progress of Ureaplasma urealyticum Infection and Infertility

WANG Yong,HAN Xiao-dong(Immunology and Reproductive Biology Lab,Medicine School of Nanjing University,Nanjing,Jiangsu,210093,China)  
Infection with Ureaplasma urealyticum(UU) leads to decline the quality of sperm, even to cause the death of sperm. UU infection causes the increase of the content of IL-6 in serum, while produces no effect on IL-6 in spermatic fluid. UU infection leads to the decrease of the content of Zn and Se in semen, therefore, the decline of spermatic quality. UU infection in animal models contributes to curl and break of the sperm, affects the secretion of cytokine, brings obvious change to the content of IL-6 and IL-8 in serum,but no obvious change to TNF-α and IFN-α.UU infection produces no obvious effect on the structures of testis, urethra and prostate but leads to the formation of calculus in urethra and bladder. In a word, UU infection is one of the factors that contribute to male infertility, the prompt treatment of which is advisable.
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