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《Progress In Veterinary Medicine》 2005-02
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Establishment of Rat Model of Osteosarcoma

YU Zhe,FAN Qing-yu,ZHANG Ting(Center of Orthopedic Surgery,Orthopedics Oncology Institute of Chinese PLA,Tangdu Hospital,Xi’an,Shaanxi,710038,China)  
To introduce a method of establishing animal model of rat osteosarcoma.Thirty 6-week-old SD rats were divided into 3 groups stchasticly. The UMR-106 cell line was injected subcutaneously into the SD rat thigh lateral at the amount of 10~5,10~6,10~7 separately.Neoplastic diameters were measured every week after inoculation to build the tumor growth curve. Five weeks later,the rats’ tumors were prepared. Pathological study was made under microscope by HE stains.The tumors of 10~5 and 10~6 groups didn’t develop well,while in the 10~7 group, the incidence of tumor was 100%.Conclusion the UMR-106 cell line has strong carcinogenic capability,which the animal models depending on it offer a way for the animal experiments of comprehensive therapy to osteosarcoma.
【Fund】: 国家自然科学基金(30330610)
【CateGory Index】: R738.1
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