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《Progress In Veterinary Medicine》 2005-05
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Progress in the Toxicity Mechanism of Cadmium

DIAO Shu-yong~(1),ZHANG Li-zhi~(2) ,YUAN Hui~(1) (1.College of Animal Science & Technology, Hunan Agricultural University, Changsha,Hunan,410128,China; 2.Iinstutute of Animal Husbandry & Veterinary ,Jinzhou Medicine College,Jinzhou,Liaoning,121001,China)  
The cadmium replaces out the intracellular enzymatic metal through combining with the mercapto-or substituting for it,which reduces the activity of the anti-oxidase, decreases the ability to clear the free radical, and causes oxidative damage of the organism. The cadmium can occupy the Ca~(2+) pathway and enter the cell,which makes the intracellular calcium out-of-balance. It also can combine with zinc location of antigen determining cluster on orphan receptor at the surface of cell before entering cell,which interferes cell's calcium metabolism; Cadmium can induce the forming of metal sulfoprotein participating in the absorption, transportation, elimination and accumulation of cadmium in the organism. It can cause DNA single strand to fragment, damage DNA repairing system, which leads to apoptosis. The mechanisms that the cadmium damage the organism are comparatively complicated and the researchers adopt different means,which have affected people's further research on cadmium toxicity mechanisms.
【Fund】: 湖南省教育厅重点资助项目(03A020)
【CateGory Index】: S859.8
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