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《Progress in Veterinary Medicine》 2007-09
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Review of the Structure and Function of the Foot-and-mouth disease virus 3C Protease

YANG Bin1,2,LIU Ji-xing2(1.College of Veterinary Medicine,Gansu Agricultural University,Lanzhou,Gausu,730070,China;2.Key Laboratory of Animal Virology of Ministry of Agriculture,State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,CAAS,Lanzhou,Gansu,730046,China)  
Foot-and-mouth disease virus(FMDV) causes Foot-and-mouth disease(FMD) of cloven-hoofed animals including cattle,sheep,et al.FMD is a highly contagious and economically devastating disease,which can impress the development of the stockbreeding of the world.FMDV belongs to the genus Aphthovirus of the family Picornaviridae.Its genome consists of a positive single-stranded RNA molecule of 8,500 nt that is translated to give a polyprotein,which is proteolytically processed to yield the mature structural and nonstructural viral proteins.The coding region can be divided into three distinct regions: P1(encoding capsid proteins VP0,VP3,and VP1,in that order),P2(nonstructural proteins),and P3(nonstructural proteins including the viral replicase).The 3C protease from foot-and-mouth disease virus is critical for viral pathogenesis,having vital roles in both the processing of the polyprotein precursor and RNA replication.Although recent structural and functional studies have revealed new insights into the mechanism and function of the enzyme,key questions remain that must be addressed before the potential of FMDV 3Cpro as an antiviral drug target can be realised.
【CateGory Index】: S852.65
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIU Yongjuan;ZHANG Fengfeng;TU Huilin;HE Xiaohua;LIU Wanhong;Pathogens and Infectious Diseases Institute, School of Basic Medical Sciences, Wuhan University;Hubei Province Key Laboratory of Allergy and Immunology;;Research progress of 2A protein of enterovirus 71[J];生命的化学;2014-06
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Ya-zhou1,2,GAN Xing2,SONG Juan2,SUN Peng2,SONG Qin-Qin2, LI Gong-qi2,SHENG Lin-jun2,WANG Bao-dong2,LU Ming-zhi2,LI Ling-min1,HAN Jun2(1.Department of Pathology,Shanxi Medical University,Taiyuan 030001,China; 2.State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention,China Center for Diseases Control and Prevention,Beijing 102206,China);The 2A Protease of Enterovirus 71 Cleaves Nup62 to Inhibit Nuclear Transport[J];病毒学报;2013-04
2 YANG Bin1,2,LIU Ji-xing2(1.College of Veterinary Medicine,Gansu Agricultural University,Lanzhou,Gausu,730070,China;2.Key Laboratory of Animal Virology of Ministry of Agriculture,State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,CAAS,Lanzhou,Gansu,730046,China);Review of the Structure and Function of the Foot-and-mouth disease virus 3C Protease[J];动物医学进展;2007-09
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