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《Progress in Veterinary Medicine》 2008-01
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Influence of the Relevant Drugs on Rat Heart Rate

LIU Ding-kuo,WANG Kai,PEI Zhi-hua,JIAO Shi,ZHOU Gui(College of Animal Science and Technology,Jilin Agricultural University,Changchun,Jilin,130118,China)  
Nicotinic acetylcholine receptors(nAchRs) are pentameric,typically being composed of α and β.To investigate which receptor subtype is active in the heart,we conducted a series of experiments using rat as model animal.Nicotine administration(100 μmol/L) caused a brief decrease-7±2% followed by a much larger increase 17±5% in heart rate and slowly returned to baseline within 10 to 15 min.The nicotine-induced decrease in heart rate could be abolished by an α7-specific antagonist,α-bungarotoxin(100 nmol/L).In contrast,the nicotine-induced increase in heart rate persisted in the presence of α-bungarotoxin.To investigate which subunits may contribute to the nicotine-induced increase in heart rate,experiments repeated were with cytisine,an agonist at nAChRs that contain β4 subunits.The results were similar to those obtained with nicotine,suggesting that the nAChRs on sympathetic nerve terminals in the heart probably contain β4 subunits.The results of this study showed that pharmacologically distinct nAChRs are responsible for the differential effects of nicotine on heart rate.More specifically,our results suggested that α7 subunits participate in the initial nicotine-induced heart rate decrease,whereas β4 subunits helped to mediate the subsequent nicotine-induced increase in heart rate.
【CateGory Index】: S859
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