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《Progress in Veterinary Medicine》 2008-01
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Phage Display Technology and Its Application

LIU Xiang-ye,DENG Hong-kuan,WU Xiu-ping,WANG Xue-lin,YU Shen-ye,YU Yan-ling,LIU Ming-yuan(Key Laboratory of Zoonoses,Ministry of Education of China,College of Animal Science and Veterinary Medicine,Jilin University,Changchun,Jilin,130062,China)  
Phage display technology is a new molecular biology technique,which can effectively linked genotype and phenotype in a same body,is and become a powerful tool in the post-genome era.Currently,the main phage used to build phage display library includes filamentous phage,λ phage,T4 phage and T7 bacteriophage.The exogenous protein that was displayed can also keep relative independent activity in the spatial structure and biological activity.With the improvement and development,this technique has been used widely in the development of new vaccines,the enzyme inhibitor screening,medical diagnosis and treatment,peptide drug development,protein interaction and so on.Furthermore,it has demonstrated a good prospect.
【Fund】: 863计划生物和医药技术领域基金(2006AA02Z451)
【CateGory Index】: Q78
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