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Pathohistological Changes on Experimental Cadmium Poisoning in Mice

LIU Feng-jun,XU Peng-peng,YANG Zi-jun,HE Jia-shuang,MA De-gang,LE Qiang (Animal Science and Technology College,Henan University of Science and Technology,Luoyang,Henan,471003,China)  
To study the effect of cadmium on normal physiological function and the testis histology and evaluate toxicity of cadmium in mice,32 six-week-old mice(both sexes) were randomly divided into 4 groups,and were intragastrically administered with cadmium whose doses were 5,7.2,10.4,15 mg/kg,respectively.The mortality in each group was recorded in 48 hours.LD50 were determined by the improved Karber's method.16 male mice were divided into 4 groups at random,and water drinked by 4 groups was added into cadmium chloridehe with 0,1.66,3.32,6.64 mg/100 mL(Cd2+),respectively,for 4 weeks.The changes of mice body weight,clinical sympotoms,pathological anatomy and pathohistology were observed within 4 weeks.As a result,The LD50 of cadmium chloridehe in mice was 9.934 mg/kg.The body weights of mice in each dose group were significantly lower than that of control at the 2nd,3th,4th week except the first week.Poisoned mice showed convulsions and other neurological symptoms,intestinal and parenchymal organ bleeding.The results showed that subchronic cadmium exposure can inhibit the growth of mice,led to megaloblastic anemia,cause mass bleeding in most visceral organs,and damage the normal physiological Structures of mice.
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