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《Progress in Veterinary Medicine》 2009-06
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Mechanism and Countermeasure of Antibacterial Drug Resistance in Animal Husbandry and Breeding

WANG Shuai-bing,XIONG Liang-wei,CHEN Xiao-lan(Jiangsu Animal Husbandry & Veterinary College,Taizhou,Jiangsu,225300,China)  
Antibacterial drug resistance in animal husbandry and breeding is becoming more and more serious.The mechanisms of antibacterial drug resistance in bacteria include producing enzyme to inactivate drug,changing the binding site of drug and expressing efflux pumps or impervious membrane to reduce drug concentration to bacteria,forming bacterial biofilm,and increasing antimetabolites etc.In recent years,many new mechanisms of antibacterial drug resistance at the molecutar level have been found out.Countermeasures must be taken to prevent antibacterial drug resistance.Some suggestions against drug resistance,such as rational administration,reinforcing the management of breeding,developing new drug,destroying the genes of drug resistance,and reducing the occurence and spread of drug resistance were summarized,which may be constructive for antibacterial drug application and development in animal husbandry and breeding.
【CateGory Index】: S852.61
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