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《Progress in Veterinary Medicine》 2010-09
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Effect of High Molybdenum Low Copper on the Structure and TNF-α Expression of Kidney in Mice

WANG Hong-wei,ZHOU Bian-hua,ZHANG Liang,ZHANG Sen,HU Wen-fa,YANG Zi-jun(College of Animal Science and Technology,Henan University of Science and Technology,Luoyang,Hehan,471003,China)  
To investigate the effect of molybdenum or copper on the structure and TNF-α expression of kidney in mice,eighty female Kunming mice were randomly divided into 4 groups.Animal models were established by adding molybdenum(600 mg/L) or copper(3 mg/L) into drinking water.On the 90th day,kidneys were collected to be researched.The results are as follows: In the high molybdenum group,the renal corpuscles closed together,some of them appeared adhesion,plenty of inflammatory cells infiltration,and a little of crescent were observed.Compare with the control group,the lever of TNF-α expression were significantly increased by 15.60% in the HM group(P0.01),The lever of TNF-α expression were significantly increased by 24.60% in the HMLC group(P0.01),compared with the control group.Compare with the HM group,the lever of TNF-α expression increased by 7.14% in the HMLC group(P0.05).The results indicated that,excessive molybdenum induced sever damage in the kidney.The level of TNF-α expression was obviously increased.Deficiency copper aggravated the molybdenum toxic action in kidney.
【Key Words】： molybdenum copper mice kidney TNF-α
【Fund】： 河南科技大学博士启动基金项目(09001368);; 河南省教育厅自然科学研究计划项目(2010B230002)
【CateGory Index】： S852.3
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