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《Progress in Veterinary Medicine》 2010-12
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Effect of Hypericin on Influenza Virus H9N2 in Vitro

WEI Lan-ping,CHEN Jian-xin,HE Zi-hua,LU Chun-ni,LI Jin-feng,HUANG Xian-hui,FANG Bing-hu(College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong,510642,China)  
To investigate anti-viral effects of hypericin on infuenza virus H9N2 in vitro,using four different administeation ways,anti-viral effects of hypericin against H9N2 were observed by MTT assay.Florometric assay was used to evaluate the inhibitory effect of hypericin on neuraminidases from influenza virus in vitro.This study showed that hypericin had multiple effects on H9N2 virus,such as prevention effect on virus adsorption,inhibition effect on virus proliferation after adsorption,direct killing virus and the effect of direct killing for 15 minutes.In above mentioned effects,the protection rate were 6.43%,5.31%,39.89%,69.04%,respectively.Hypericin also had obvious activity on inhibiting the neuraminidase,the IC50 values was 0.58 mg/mL.As a conclusion,hypericin has protective effect against influenza virus in vitro and potent inhibitory effects on influenza virus H9N2 neuraminidase.
【CateGory Index】: S853.7
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