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《Progress in Veterinary Medicine》 2014-10
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Study on Pharmacokinetics of Avermectin Nanometre Liposomes in Goats

SUN Xue-feng;ZHANG Yao-qi;XU Xian-hui;DANG Li-mei;LIU Dan;LI Hui-fang;LIU Yi-lin;LI Yin-qian;Animal Pharmaceutical Co.Ltd of Henan Huitongtianxia;College of Veterinary Medicine,Northwest A&F University;  
Pharmacokinetics in goats was studied after subcustaneous avermectin nanometre liposome injection.The avermectin nanometre liposomes concentration in serum was determined by HPLC after extracted from serum by ethyl acetate several times and evaporated through nitrogen stream.The pharmacokinetic characteristics of avermectin in goats were fitted with classic absorbable one-compartment model.Main pharmacokinetic parameters were as followings:absorption half time t1/2Ka=0.24±0.03 d,elimination half time t1/2Ke=6.74±0.80 d,the highest drug concentration in serum Cm=60.76±5.62ng/mL,area under the concentration time curve AUC=664.35±28.14ng/mL)·d,peak time Tp=1.20±0.08 d.The result showed that effective time of avermectin maintained was more than 30 days.As a result,the release effect of avermectin nanometre liposome was determined,which can be used as long-acting formulations of avermectin in further study.
【Fund】: 郑州市重点科技攻关项目(115PCXJY546)
【CateGory Index】: S859.79
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