Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Progress in Veterinary Medicine》 2014-10
Add to Favorite Get Latest Update

Study on Pharmacokinetics of Avermectin Nanometre Liposomes in Goats

SUN Xue-feng;ZHANG Yao-qi;XU Xian-hui;DANG Li-mei;LIU Dan;LI Hui-fang;LIU Yi-lin;LI Yin-qian;Animal Pharmaceutical Co.Ltd of Henan Huitongtianxia;College of Veterinary Medicine,Northwest A&F University;  
Pharmacokinetics in goats was studied after subcustaneous avermectin nanometre liposome injection.The avermectin nanometre liposomes concentration in serum was determined by HPLC after extracted from serum by ethyl acetate several times and evaporated through nitrogen stream.The pharmacokinetic characteristics of avermectin in goats were fitted with classic absorbable one-compartment model.Main pharmacokinetic parameters were as followings:absorption half time t1/2Ka=0.24±0.03 d,elimination half time t1/2Ke=6.74±0.80 d,the highest drug concentration in serum Cm=60.76±5.62ng/mL,area under the concentration time curve AUC=664.35±28.14ng/mL)·d,peak time Tp=1.20±0.08 d.The result showed that effective time of avermectin maintained was more than 30 days.As a result,the release effect of avermectin nanometre liposome was determined,which can be used as long-acting formulations of avermectin in further study.
【Fund】: 郑州市重点科技攻关项目(115PCXJY546)
【CateGory Index】: S859.79
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 7 Hits
1 ;Pharmacokinetics of oral ketoconazole microcapsule in rabbits[J];Academic Journal of Second Military Medical University;2006-07
2 YI Jin-e,YUAN Hui,YUAN Li-yun,LIU Jin-hui,TU Di,JIANG Ke(College of Veterinary Medicine,Hunan Agricultural University,Changsha,Hunan,410128,China);Study on Acute and Subchronic Toxicities of Avermectin Microcapsule in Rats[J];Progress in Veterinary Medicine;2008-02
3 HE Ji-hong1,SHENTU Fen-qin2 (1.China Animal Husbandry Industry Co.,Ltd,Beijing,100070,China;2.Beijing Shijiyuanheng Co,.Ltd,Beijing,100085,China);Progress on Techniques for Detecting Residues of Aermectins[J];Progress in Veterinary Medicine;2009-05
4 QIN Gai-xiao1,XU Wen-yan1,AI Xiao-hui2,TANG Guo-pan1,CUI Jin1, LI Xiang-hui1,YUAN Ke-ping2(1.Zhengzhou College of Animal Husbandry Engineering,Zhengzhou 450011,China; 2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Wuhan 430223,China);Studies on the pharmacokinetics and residues of avermectin in grass carp(Ctenopharyngodon idellus) after single oral administration[J];Freshwater Fisheries;2012-04
5 LI Ming;FENG Wei;LI Shu;School of Life Science,Daqing Normal University;School of Veterinary Medicine,Northeast Agricultural University;;Research advances of avermectins toxicology on non-target animals[J];Journal of Northeast Agricultural University;2013-12
6 WT5BZ]Wang Minru,Chen Zhangliu,Feng Qihui [WT5BX](Department of Veterinary Medicine,South China Agricultural University,Guangzhou 510642)[WT5HZ];PHARMACOKINETIC PROPERTIES OF IVERMECTIN LOADED PLA MICROSPHERES IN RABBITS[J];CHINESE JOURNAL OF ANIMAL AND VETERINARY SCIENCES;2000-02
7 Pan Baoliang, Wang Yuwan, Wang Ming (College of Veterinary medicine , China Agricultural University, Beijing 100094;China);Comparation of Pharmacokinetics of Prolonged Injection and Common Injection of Avermectin in Sheep[J];Chinese Journal of Veterinary Drug;2003-03
Chinese Journal Full-text Database 10 Hits
1 Jia Shuqin (Ninxia Traditional Chinese Medicine Factory, Yinchuan 750011);APPLICATION OF POLYMERS IN THE PHARMACEUTICAL PREPARATIONS[J];Engineering Plastics Application;2000-06
2 XU Ji-heng,MA Feng-yu,ZHOU Ya-qiu(Department of Pharmacy,Anhui College of Traditional Chinese Medicine,Hefei 230031,China);Research Survey of Sustained Release Tablets[J];Anhui Chemical Industry;2011-01
3 TANG Li Qin, LIU Sheng, CHEN Li Ming, CHEN Xiang Qing, TIAN Li (Anhui Provincial Hospital, Hefei 230001);Selection of excipient on compound folium sennae pellets[J];Anhui Medical and Pharmaceutical Journal;2002-04
4 CHENG Ming(Huaibei Institute of Drug Contral,Huaibei,Anhui Provide 235000);Role of hydrixypropyl β-cyclodextrin in increasing the solubility if voriconazole[J];Anhui Medical and Pharmaceutical Journal;2007-03
5 WU Jin,LI Zhi-hao,LI Peng,ZHENG Fang(Department of Pharmacy,Dongfeng Hospital Affiliated to Yunyang Medical College,Shiyan,,Hubei 442008);Determination of drug release in vitro of ligustilide liposome by RP-HPLC[J];Anhui Medical and Pharmaceutical Journal;2010-06
6 GUI Shuang-ying,WEN Zhi-qiang,PENG Dai-yin,KAI Wei-hua(Department of Pharmacy,Anhui College of Traditional Chinese Medicine & Anhui "115" Innovation Team for Research and Development of modern Chinese Materia & Anhui Engineering Research Center for Modern Chinese Materia Medica,Anhui Hefei 230031,China);Determination of Entrapment Efficiency of Tetrandrine Liposomes[J];Journal of Anhui Traditional Chinese Medical College;2009-05
7 Hou Fangjie Song Junna;The technology of Cyclodextrin and its application in Traditional Chinese Medicine Pharmacy[J];Journal of North Pharmacy;2011-02
8 Xiong Yang,Liu Yong,Deng Fengjun Zhejiang College of TCM,Hangzhou(310053);Research on Compound of Volatile oil of Atracty Loades Macrocephala and Citri Reticulatae[J];Journal of Zhejiang College of Tcm;2005-05
9 ;Preparation of inclusion complex of nitrendipine-β-cyclodextrin[J];Journal of Jilin University of (Medicine Edition);2005-05
10 LIU Fuqing, HAN Yuxia, SUN Huijing, et al (Medical Department,Binzhou Vocational College,Binzhou 256600);INDUCTION OF Cl_2 MBP-LIPOSOME FOR APOPTOSIS OF MACROPHAGES[J];Journal of Binzhou Medical College;2004-04
China Proceedings of conference Full-text Database 10 Hits
1 WANG Hua-ming,WANG Jiang,CAO Yang ( Schoole of Material and Chemical Engineering, Hainan University, Ministry of Education Key Laboratory of Application Technology of Hainan Superior Resources Chemical Materials, Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti Resources, Haikou 570228, China);Preparation and application of starch microsphere[A];[C];2009
2 Tian Jing - zhen , Zhang Yu - juan (Shandong University of Traditional Chinese Medicine , 250014 );Achance in liposomes[A];[C];2005
3 Tian jing hui,Xu jian bin,Wangwei,Qian pei pei,Caokai,Li xiao man Pharmacy College of Henan University,Kaifeng,Henan,475004;Study on the release of Piractam permeating membrane in vitro[A];[C];2010
4 ;纳米药物与肿瘤靶向治疗[A];[C];2010
5 ;Stndyon Preparation and in vitro drug release of docetaxel polylactic acid microsphere[A];[C];2006
6 ;SLB脂质纳米粒小鼠体内外相关性研究[A];[C];2008
7 SHEN Yuan-yuan, QIU Li-yan, JIN Yi College of Pharmaceutical Science, Zhejiang University, Hangzhou 310031, China;Preparation and Quality Evaluation of Lomustine Containing Liposomes[A];[C];2006
8 WANG Hongliang, WANG Renyun, LIU Yuling (Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050, China);The glass transition temperature and release chapter study of Thymopentin continuous release Microspheres[A];[C];2006
9 ;Study on Preparation of Helicidum Sustained-release Pellets[A];[C];2006
10 DONG Di,LIU Hong-Mei,SONG Xiao-Dan, ,DU Xia ,WU Lin-Hua* (Derpartment of Pharmcy,the second Affiliated Hospital of Harbin Medical University,Harbin 150081,China);RP-HPLC Determination of Content and Entrapment Efficiency of Itraconazole in Liposome[A];[C];2006
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 XING Cai hong, DAI Yu fei, CHANG Ping, et al (Institute of Occupational Medicine,Chinese Academy of Preventive Medicine, Beijing 100050, China);STUDIES ON THE MUTAGENICITY, TERATOGENICITY AND SUBCHRONIC TOXICITY OF METHYLAMINO ABAMECTIN[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;2000-03
2 ZHOU Liangsheng1,2,LI Shu1,ZHU Beilei3,SHEN Jianzhong3(1.College of Veterinary Medicine,Northeast Argricultural University,Harbin 150030,China;2.Animal Science and Veterinary Medicine Bureau of Aihui District,Heihe 164300 Heilongjiang,China;3.College of Veterinary Medicine,China Argricultural University,Beijing 100094,China);Apoptosis of king pigeon cerebrum caused by subacute avermectin poisoning[J];Journal of Northeast Agricultural University;2009-02
3 Chen Shenlin, Zhang Chuan, Liu Qi, Li Guodong, Zhao Lei ((Department of Pharmaceutics, College of Pharmacy, Second Military Medical University, Shanghai, 200433);The study of pharmacokinetics of intravenous injection and vaginal suppository of ketoconazole in goats[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1998-04
4 GUI Li1,TIAN Hong1,ZHENG Jian1,DUAN Wei1,YE Feng2(1Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037;2Department of Chemical Defense,College of Military Preventive Medicine,Third Military Medical University,Chongqing 400038,China);Simultaneously determining 4 amino acid neurotransmitters in mice brain by high-performance liquid chromatography with fluorescence detector[J];Acta Academiae Medicinae Militaris Tertiae;2009-08
5 WANG Jian-pei~1,2,OUYANG Wu-qing~1(1.College of Animal Science and Technology,Northwest University of A & F,Yangling,Shaanxi,712100,China;2.Fangzheng Animal Medicine Factory in Urumqi High New Technology Industrial Development Area,Urumqi,Xinjiang,830000,China);Application of Slow Release Compound Preparation of Avermectin Against Sheep Parasitic Diseases[J];Progress in Veterinary Medicine;2006-04
6 YI Jin-e,YUAN Hui,YUAN Li-yun,LIU Jin-hui,TU Di,JIANG Ke(College of Veterinary Medicine,Hunan Agricultural University,Changsha,Hunan,410128,China);Study on Acute and Subchronic Toxicities of Avermectin Microcapsule in Rats[J];Progress in Veterinary Medicine;2008-02
7 SHANG Bei cheng,XU Gui li,ZHANG Qing,TANG Bing,LIU Tao (Kunming General Hospital of Chengdu Military Command,Kunming,China 650032);Preparation and Determination of the Microcapsules of Ketoconazole[J];Academic Journal of Guangdong College of Pharmacy;2001-04
8 LONG Qi-Cai1 REN Bin2 LI SHu-Xia2 ZENG Gut--Xiong1 1(Department of Clinical Pharmacology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080) 2(Department of Pharmacy The First Affiliated Hospital, Sun Yat-sen University of Medical Scien-ces, G;Human Pharmacokinetics of Orally Taking Ivermectin[J];The Chinese Journal of Clinical Pharmacology;2001-03
9 REN Rui, LI Ben-chang, ZHENG Jing,et al.College of Public Health,Harbin Medical University,Harbin,Heilongjiang 150081,China;Effects of Avermectine on the Nerve Metabolism Enzyme in Cerebrum of Rats[J];Journal of Environment and Health;2009-02
10 YI Jin-e,SUN Zhi-liang,LIU Jin-hui,XU Jian-ping,ZHOU Ke-yan(College of Animal Science and Technology,HNAU,Changsha 410128,China);Preparation and in Vitro-Release of Avermectins Microcapsule[J];Journal of Hunan Agricultural University(Natural Sciences);2006-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved