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《Progress in Veterinary Medicine》 2015-03
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Effect of Astragalus and Acanthopanax Decoction on Immune Function in Mice

SU Meng;YANG Liu;HOU Jing-ling;LI Mu;ZHONG Xiu-hui;College of Veterinary Medicine,Hebei Agricultural University;College of Traditional Chinese Veterinary Medicine,Hebei Agricultural University;  
The aim of this study was to investigate the effect of Astragalus and Acanthopanaxdecoction on immune function in mice.6week old female Kunming mice were randomly divided into normal mice groups(control group,high-,mediate-,low dose group)and immunosuppressive mice groups(normal control,Hy+ distilled water group,Hy+ high dose group,Hy+ mediate dose group,Hy+ low dose group).The mice were intragastrically administrated for 7days,and the immune organ index,the carbon clearance index,the levels of serum hemolysin and spleen antibody forming cell(PFC)were tested.The result showed that the high,middle dose Astragalus and Acanthopanaxdecoction can significantly improve the normal mice spleen index(P0.01),all treated groups could significantly increase the thymus index(P0.01 or P0.05)and the carbon clearance index(P0.01)in normal mice,there was significantly increase of the level of serum hemolysin in high dose group,the three treated groups had no significant effect on PFC in normal mice;Each dose Astragalus and Acanthopanaxdecoction can improve the immune spleen index,thymus index,the carbon clearance index,the levels of serum hemolysin and PFC significantly(compared with Hy+ distilled water group P0.01 or P0.05),and recovered to the normal level(compared with normal control group P0.05).
【Fund】: “十二五”国家科技支撑计划项目(2011BAD34BO2)
【CateGory Index】: R285.5
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