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Advances in bone morphogenetic protein 2 in treatment of femoral head necrosis

With the development of tissue engineering, bone morphogenetic protein(bone morphogenetic protein, BMP) applications study is becoming more and more widely in the field of orthopedics,The therapeutic effect of bone morphogenetic protein-2(bone morphogenetic protein, BMP-2) including bone defects,nonunion and other aspects have been demonstrated on the basis of experimental and clinical practice[1-3],Its mechanism may be BMP-2 can induce differentiation of mesenchymal stem cells into cartilage direction,conduct through Smad pathway and MAPK pathway,and promote bone formation, tissue growth and damage repair[4]. Based on this mechanism of action, more and more scholars have putted study focuses on the field of femoral head necrosis treatment, this article makes a brief summary of the treatment of femoral head necrosis advances of BMP-2 in recent years.
【CateGory Index】: R681.8
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【Citations】
Chinese Journal Full-text Database 10 Hits
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
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