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《CHINESE ARCHIVES OF OTOLARYNGOLOGY-HEAD AND NECK SURGERY》 1997-05
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A preliminary study on the course of treatment of hyperbaric oxygen therapy in patients with idiopathic sudden hearing loss

Lu Xuemei; Zhang Suhua(From the Department of Otolaryngology, Head and Neck Surgery, People's Hospital ofLiaocheng Prefecture, Shangdong Liaocheng 252000)  
Free radical metabolism substance in different stages of hyperbaric oxygen (HBO) therapy in 33 patients with idiopathic sudden hearing loss were studied. There were 20 males and 13 females, raging in age from 15 to 58 years. The duration of treatment is 40 min. per day and the pressure of HBO is 0. 2 MPa. The whole treatment lasted for 20 days. After ten times of HBO therapy, the level of lipid peroxidase (LPO) in plasma in-creased slightly and the activities of superoxide dismutase (SOD) and glutathione perox-idase (GSHPx) in erythrocytes decreased not significantly (P 0. 05). Only the levels of glutathione (GSH) in erythrocytes decreased significantly (P 0. 05). After 20 dyas of HBO therapy, the plasma LPO value increased significantly (P 0. 001) whereas the activities of SOD, GSHPx and the values of GSH in erythrocytes decreased significantly (P 0. 001). It seemed useful to treat patients with HBO 40 min. per day with pres-sure of 0. 2 MPa. Contineous thrapy shuld not be carried out over 20 days. A course of treatment for ten days should be sufficient.
【CateGory Index】: R764
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