Effect of Ibudilast on the quality of life of patients with steroid resistant allergic rhinitis:a randomized,double blind,controlled study

LUO Hong~(1,2) LIU Xiaoling~1 TAO Zezhang~2 YAN Nengbing~1 PAN Guangzhen~1 JIANG Yan~1 YU Ye~1 LI Jiangping~1 (1 Department of Otolaryngology,the Central Hospital of Xiangfan City,Affiliated Xiangfan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Xiangfan,Hubei,441021,China; 2 Department of Otolaryngology Head and Neck Surgery, People's Hospital of Wuhan University,Wuhan,Hubei,430060,China)  

OBJECTIVE To assess the effect of Ibudilast on the quality of life (QOL) of patients with steroid resistant allergic rhinitis.METHODS A randomized,double-blind,placebo-controlled study was carried out with Ibudilast in 66 patients with the steroid resistant allergic rhinitis.QOL was measured with Short-Form Health Survey (SF-36) questionnaire (Chinese version).Ibudilast (10rag twice daily,34 patients),placebo (32 patients) was given for 3 weeks. The SF-36 questionnaire was administered at the start of treatment and after 3 weeks of treatment.Sings and Symptom-medication scores were measured daily during the study.RESULTS There were no significant differences between the Ibudilast and placebo group in terms of sings and symptoms or QOL scores before study.After 3 weeks of treatment,symptoms scores were significantly decreased and QOL scores significantly improved in the Ibudilast group compared with those in placebo group (both P0.001,t test).All of the 8 QOL dimensions were significantly improved (from P=0.001 to P0.001,F test) after 3 weeks of Ibudilast treatment.There was no improvement in the placebo group.CONCLUSION Ibudilast not only can decrease sign and symptom scores,but also can improve the QOL in patients with steroid resistant allergic rhinitis.Placebo can relieve the signs and symptoms,but can not improve the QOL.

【Key Words】： Rhinitis Allergic Perennial Hormones Drug Resistance Quality of Life Questionnaires
【CateGory Index】： R765.21
【DOI】： CNKI:SUN:EBYT.0.2008-11-013

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