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Effects of the polygonatum sibiricum polysaccharides on blood glucose in mice and their initial mechanical study

WANG Hongling,ZHANG Yuhou,HONG Yan,LIU Junyan(The Pediatrics, Zhong Nan Hospital of Wuhan University, Hubei 430071)  
Objective: To explore the effects of the P.sibiricum polysaccharides (PSP) on the blood glucose of mice. Methods: The normal mice and the hyperglycemic mice are divided into five groups: large, middle, small dose groups of PSP, positive control group, normal control group. Then we measure the blood glucose of all groups and hepatic adenosine-3′, 5′-cyclic monophosphate (camp) of the adrenalin mice model respectively. Results: The polysaccharides have no significant effects on the blood glucose of normal mice, but could remarkably decrease it in those of the adrenalin mice model, and the best effect can be reached with the dose of 500 mg per kilogram. And the polysaccharides decrease the amount of hepatic cAMP in the adrenalin mice model at the same time. Conclusion: The blood glucose's lowering action of PSP closely correlates with its reducing the amount of hepatic cAMP.
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