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《Journal of Pediatric Pharmacy》 2004-05
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Effect of ambroxol on airway reaction in the guinea-pig with asthma

ZHENG Yan-hui1,ZHENG Bing2(1.Changsha Railway Hospital of hunan province,Hunan Changsha 410001,China; 2.Hunan Institute of Traditional Chines Medtcine,Hunan Changsha 410013, China)  
Objective: To investigate the effect of ambroxol on airway reaction in asthma guinea-pig. Methods: 18 guinea-pigs were randomized into normal control group, bronchial asthma group and ambroxol group. Allergic bronchial asthma was induced with injection of 10% OVA intraperitoneally (i.p.) according to the literature report. Airway reactivity of the animals in three groups was measured on the fifteenth day after the last stimulation with endotracheal intubation under anesthesia and artificial ventilation. Results: Airway reaction in ambroxol group and the normal control were lower than that of bronchialasmatic group (P 0.01). Conclusions: Ambroxol can reduce airway reaction, which leads to improve airway inflammation, and main pathophysiological processes of bronchial asthma in guinea-pig and has a certain function in preventing and treating bronchial asthma.
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Hong Zhigang, Liu Shengyuan, Wang Dixun Department of Pathophysiology, School of Basic Medical Sciences, Tongji Medical University,Wuhan 430030;The Measurement of Airway Responsiveness in Small Animals[J];ACTA UNIVERSITATIS MEDICTNAE TANGJI;1999-04
2 DAI Jihong, TAN Yi, FU Zhou (Children's Hospital of Chonqing University of Medical Science, Chonqing 400014,China);The Current Situation of Researches on Animal Model of Asthma[J];Chinese Journal of Laboratory Animal Science;2001-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WU Hong-tao,MA Xiao-lin,JIANG Yao-guang (Trauma Center,Institute of Surgery Research,Daping Hospital,Third Military Medical University, Chongqing 400042,China);Study of mucosolvan treatment of traumatic ALI in rabbits[J];Journal of Traumatic Surgery;2005-01
2 ZHENG Yan-hui,KUAN Shou-jing.Department of Pediatvics The 3rd Xiang Hospital,Central South University,Changsha,410013,China;Effect of Small and Large Ambroxol on Pulmonary Surfactant in Asthma Guinea-pig[J];Journal of Chinese Physician;2003-S1
3 Feng Shi-jun Department of ICU,Hospital of Qiyang People,Qiyang 426100,China;Experience of Using Large Dosage Mucosolvan and End-expiratory Positive Pressure Mechanical Ventilation in 30 Patients with Acute Respiratory Distress Syndrome[J];Chinese Journal of Medicinal Guide;2008-01
4 HUANG Ying, PENG Donghong, ZHANG Ruyi(Department of pulmonary, Children Hospital of Chongqing Medical University 400014);Ambroxol used as an add-on therapy for bronchiolitis[J];Journal of Pediatric Pharmacy;2002-04
5 ZHANG LiQing, WU Ju ( The Children's Hospital of Chendu 610016);The clinical observation of mucosolvan on the treatment of capillary bronchitis[J];Journal of Pediatric Pharmacy;2003-01
6 ZHU Ying-qun (The Third Municipal Hospital of Changsha, Changsha 410015, Hunan, China);The effect of ambroxol against airway inflammation of patients with chronic obstructive pulmonary disease[J];Hainan Medical Journal;2006-12
7 LI Chun-hua, GONG Xian-ming, HUANG Hai-zhong (Hui zhou People’s Hospital, 516002, China);Clinical observation of Treating Capillarity Bronchitis with Bromhexine Hydrochloride[J];Hainan Medical Journal;2007-07
8 ZHANG Zuo-qing,ZHANG Chang-hong(Department of Respiratory Disease,Shijingshan Hospital of Beijing City,Beijing 100043,China);Curative Effect Observation on Senile Pneumonia Treated with Mucosolvin[J];Heilongjiang Medical Journal;2007-06
9 NIE Lei, LIU Yi-qi, YANG Jin-song(Department of Cardiothoracic Surgery,The Peoele’s Hospital of Hunan, Changsha 410005);Impact of Infusing Ambroxol Before Cardiopulmonary Bypass upon Lung Injury[J];Journal of Clinical Research;2006-10
10 SONG Xiao,WU Cheng-qin(Health Center,Child Welfare Hospital of Hangzhou,Hangzhou,Zhejiang 311106,China);Application of auxiliary spray inhalation with mucosolvan in treating infants with bronchopneumonia[J];Journal of Hangzhou Teachers College(Medical Edition);2008-06
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Li Huige;Wang Dixun (Department of Pathophysiology,School of Basic Medical Sciences,Tongji Medical University,Wuhan 430030);Measurement of Respiratory Mechanics in Experimental Animals[J];ACTAUNIVERSITATIS MEDICTNAE TANGJI;1995-02
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