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《Journal of Pediatric Pharmacy》 2004-05
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Effect of ambroxol on airway reaction in the guinea-pig with asthma

ZHENG Yan-hui1,ZHENG Bing2(1.Changsha Railway Hospital of hunan province,Hunan Changsha 410001,China; 2.Hunan Institute of Traditional Chines Medtcine,Hunan Changsha 410013, China)  
Objective: To investigate the effect of ambroxol on airway reaction in asthma guinea-pig. Methods: 18 guinea-pigs were randomized into normal control group, bronchial asthma group and ambroxol group. Allergic bronchial asthma was induced with injection of 10% OVA intraperitoneally (i.p.) according to the literature report. Airway reactivity of the animals in three groups was measured on the fifteenth day after the last stimulation with endotracheal intubation under anesthesia and artificial ventilation. Results: Airway reaction in ambroxol group and the normal control were lower than that of bronchialasmatic group (P 0.01). Conclusions: Ambroxol can reduce airway reaction, which leads to improve airway inflammation, and main pathophysiological processes of bronchial asthma in guinea-pig and has a certain function in preventing and treating bronchial asthma.
【CateGory Index】: R96
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