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《Journal of Pediatric Pharmacy》 2007-02
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An analylsis of the application of the third generation cephalosporins and the antibiotic resistance of gram negative bacilli

WANG Gang1, CHEN Yuan1, KUANG Feng-wu1, LIU Enmei1, XIONG Wan1, LIU Zhuoyi1, HUANG Ying1, LIU Lan1, SHEN Xu-zhuang2,YANG Yong-hong2 (1.Children’s Hospital of Chongqing Medical University, Chongqing 400014,China; 2. Capital University of Medical Sciences Affiliated Beijing Children’s Hospital, Beijing 100045, China)  
Objective:To learn the application of the third generation cephalosporins (TGC) and the resistance of gram negative bacilli (GNB). Method: Based on the hospital information system (HIS), numerical data about TGC consumption from 2002.1 to 2005.12 were collected. The utilizing frequency of TGC were calculated. The suceptibility tests were performed on the GNB separated from the clinical samples and the results were analyzed. Results: The percentage of the DDDs and the amount of money of TGC in the 4 years were 6.42% and 15.23% respectively and the major 4 kinds of drugs were ceftriaxone, cefotaxime, ceftazidime and cefoperazone. 67.96% seperated microbes was GNB and Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Hemophilies influenzae occupied the top 4. Drug fast rates of GNB to the 4 TGCs were 45.56%, 40.19%, 47.75% and 48.28% respectively. There is a direct correlation between the DDDs of TGC and the drug fast rates. Conclusions: To regularize the application of TGC is important for inhibiting the fast increasing drug resistance of GNB.
【Fund】: 国家“十五”科技公关项目(2004BA720A09-01)
【CateGory Index】: R446.5
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