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《Journal of Pediatric Pharmacy》 2007-03
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A clinical observation on efficacy of ribavirin spray on herpangina

HE Shuang-wen (The people's Hospital of Gongyi City,Henan Gongyi 451200,China)  
Objective:To observe the clinical efficacy of ribavirin spray in treating herpangina.Methods:76 cases with herpangina were randomly divided into the control group of 36 cases and the treatment group of 40 cases.Two groups were given regular treatment,with the treatment group given ribavirin spray in addition,once every 2 hours,total 8 times on first day and every 4 hours,4 times a day,2~3 sprays for each time on the following 5 to 7 days.Results:The total effective rate and the rate of excollent effect in treatment group were 92.5% and 70.0% respectively, and 72.2% and 38.9% in control group and the physical signs such as body temperature,oral ulcer got better in a shorter time in the treatment group than in the control group,so there was a significant difference between the two groups.Conclusions:Ribavirin spray could be effectively and safely used in treating herpangina with little side effects.It can he used as a first choice for herpangina.
【CateGory Index】: R766
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【References】
Chinese Journal Full-text Database 1 Hits
1 Pang Guo-Xiang,Lin Shao-Zhu,Zhang Zhen-Hua Department of Pediatrics,People,s Hospital of Longgang District,Shenzhen,518172,China Department of pediatrics,the affiliated hospital of Guangdong Medical Couege,Zhanjiang,254001,China;Evaluation of the efficiency and safety of Redunin injection in treating Herpangina of children[J];Nei Mongol Journal of Traditional Chinese Medicine;2008-10
【Citations】
Chinese Journal Full-text Database 1 Hits
1 HONG Jian-guo,LI Zhen,CAO Lan-fang1, CHEN Pei-li2, WANG Li-bo3, BAO Yi-xiao4,GU Hong-liang5.Department of Pediatrics,the First Affiliated Municipal Hospital,Shanghai Jiaotong University,Shanghai 200080,China(1. Renji Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200001,China;2.Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China;3.Children's Hospital of Fudan University,Shanghai 200032,China;4.Xinhua Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200092,China;5.The Ninth Affiliated Municipal Hospital,Shanghai Jiaotong University,Shanghai 200011,China);Effect of ribavirin aerosol on viral infection of upper respiratory tract in children: a multicenter clinical observation[J];The Journal of Clinical Pediatrics;2006-06
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 WANG Yu(The First Hospital of Third Military Medical Univesity of Chines PLA,Chongqing 400038,China);To study the therapeutic effects of three different administrative methods for herpangina and evaluating the curative effect of Rb-bFGF[J];Journal of Pediatric Pharmacy;2005-05
2 Fan Zheng,et al;Pathogenic study on herpes pharyngitis in children[J];Zhejiang Clinical Medical Journal;2008-05
3 ;Effect Observation of Aciclovir in Treatment of Herpetic Angina by Local Douche[J];Journal of Henan University of Science and Technology(Medicial Science);2004-02
4 ZHAO Bao-zhen,ZHAO Zhi-ming Department of Pediatric,Chinese People's Armed Police Force College Hospital,Langfang 065000,China;Effect of ribavirin aerosol on herpetic angina of children[J];Journal of Chinese PLA Postgraduate Medical School;2009-05
5 ZHONG Guo-yu,CHEN De-hui,LI Jin-ying,et al.(The First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,Guangdong,P.R.China);Clinical observation on the results in treatment of cough children by inhalation of Budesonide and Ribavirin[J];China Tropical Medicine;2007-04
6 NI Jun-ping.Big-stone People's Hospital in Panyu District,Guangzhou Guangdong 511430,China.;Clinical analysis on ganciclovir in treatment of herpangina in children[J];Journal of Clinical and Experimental Medicine;2009-05
【Co-references】
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1 HUANG Yao(the Affiliated Taizhou Hospital of Wenzhou Madical College,Zhejiang Wenzhou 317000,China);Therapeutic effects of ganciclovir and aciclovir in the treatment of hepetic angina[J];Journal of Pediatric Pharmacy;2005-05
2 JI Jian-bing,LI Hai-yan(The People's Hospital of Rugao,Jiangsu Rugao 226500,China);Analyzing the Effect of Reduning Injection on Child Epidemic Parotitis[J];Hebei Medicine;2007-06
3 FENG Gan-zhu,ZHOU Feng1,HUANG Mao2,YAO Kun1 (Department of Respiratory,the Second Affliated Hospital of NJMU,Nanjing 210011;1Department of Microology-Immunology,NJMU,Nanjing 210029; 2Department of Respiratory, the First Affliated Hospital of NJMU,Nanjing 210029,China);Anti-respiratory syncytial virus(RSV,Long strain) effect of Reduning inject on in vitro[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2007-09
4 FENG Gan-zhu~1 ZHOU Feng~2 HUANG Mao~3 YAO Kun~2 (1.Department of Respiratory Medicine,the Second Affiliated Hospital of Nanjing Medical University,Nanjing JIANGSU 210011,China;2.Department of Micrology and Immunology,Nanjing Medical University,Nanjing JIANGSU 210029,China;3.Department of Respiratory Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing JIANGSU 210008,China);Inhibitory effects of Reduning injection on adenovirus type-3 in vitro[J];Chinese Journal of New Drugs and Clinical Remedies;2007-08
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