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《Journal of Pediatric Pharmacy》 2007-04
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Changes of platelet parameter and of T lymphocyte subsets in children with Kawasaki disease

ZHOU Jian,JIANG Hong (Changzhou NO.2 Hospital, affiliated to Nanjing Medical University, Jiangsu Changzhou 213003, China)  
Objective: To explore the changes of platelet parameter and of T lymphocyte subsets in children with Kawasaki disease. Methods: Automatic blood analyzing apparatus and flow cytometry were applied to inspect the platelet total (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) in 48 cases with KD, and the serum level of T lymphocyte subsets in 30 cases with KD respectively. Results: The levels of PLT, MPV, PDW, PCT increased remarkably. There was a peak in the platelet parameter in third week. The level of CD3+, CD4+ T cell and the ratio of CD4+/CD8+ decreased significantly (P0.05) in comparison with the controlled group, but the CD8+ and NK had no remarkable difference (P0.05). Conclusions: The platelet played an important role in KD’s blood vessel inflammation and the function of cellular immunity was low in the children with KD.
【CateGory Index】: R725.4
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