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《Chinese Journal of Child Health Care》 2004-06
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Effect of high-fat-diet on serum glucose,triglyceride,leptin and insulin sensitivity in obesity-susceptible and obesity-resistant rats.

ZHAO Fei,WANG Yu-wei,LIU Xin-jie,YANG Jie.(Department of Pediatrics,Qilu Hospital,Shandong University,Jinan,Shandong 250012,China)  
Objective To study the effect of high-fat-diet on serum glucose,triglyceride,leptin and insulin sensitivity in obesity-susceptible and obesity-resistant rats. After fed with high-fat-diet for 8 weeks,rats were divided into obesity-susceptible and obesity-resistant subgroups according to weight, and variables indexes were measured. The serum glucose,triglyceride were significantly higher in obesity-susceptible and obesity-resistant rats,but leptin resistance and insulin resistance were present only in obesity-susceptible rats. [Conclusion] The obesity-resistant rats also existed metabolic disorder,but had much less tendency to become leptin resistance and insulin resistance than obesity-susceptible rats.
【Fund】: 博士论文课题
【CateGory Index】: R723
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