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《Chinese Journal of Child Health Care》 2005-03
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Changes in apoptosis and Fas/FasL expression in newborn rats with acute lung injury.

LV Hui, WAN Gen-ping, CHEN Ke-zheng, HUANG Xiao-hong. (Department of Neonatology, the Children Hospital of Guangzhou,Guangzhou, Guangdong 510120, China)  
【Objective】To observe the expression of apoptosis related gene Fas/FasL on lung injury caused by hypoxia and inhaled 100% O_2 after hypoxia. Two lung injury rat models were established by hypoxia or inhaled 100% O_2 respectively. Apoptosis of the lung tissue was observed with the methods of Tunel and in situ hybridization. mRNA expression of Fas/FasL was detected by SqRt-PCR. Apoptosis of rat pulmonary alveolar epithelial cells and pneumoangiogram endothelial cells appeared after 4 hours in two groups. And the index of apoptosis increased with the time passing by ( P =0.003, 0.005 respectively). And expression of Fas/FasL mRNA was up-regulated in two groups, which in inhaled pure oxygen group was higher than in hypoxia group. [Conclusion] Apoptosis and upregulated Fas/FasL mRNA plays an important role on lung injury which is caused by hypoxia or inhaled pure oxygen after hypoxia.
【Fund】: 广东省医学科研基金项目(A2002597);; 广州医学院科研基金项目(01 k 06)
【CateGory Index】: R563
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Chinese Journal Full-text Database 1 Hits
1 CHEN Ke Zheng, WANG WeiDepartment of Neonatology, Guangzhou Children's Hospital, Guangzhou 510120, China;Pulmonary Hemorrhage Model of Neonatal Rats and Its Clinical Significance[J];Chinese Journal of Contemporary Pediatrics;2002-05
Chinese Journal Full-text Database 7 Hits
1 HE Liu-Fang, CHEN Ke-Zheng. Department of Neonatal Intensive Care Unit, Guangzhou Children′s Hospital, Guangzhou 510120,China;The construction and identification of siRNA expression vector against hypoxia inducible factor-1α in vitro[J];Chinese Journal of Contemporary Pediatrics;2008-01
2 DONG Hong, LIU Bao song, WANG Zhi wen (Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Changes and significance of lung cell apoptosis in rat after chest impact[J];Acta Academiae Medicine Militaris Tertiae;2001-02
3 Chen Kezheng, Wang Wei, Lu Hui. Department of Neonatology, Guangzhou Children's Hospital, Guangzhou 510120;The relationship between endothelin-1(ET-1), calcitonin gene related peptide(CGRP) and oxygenic free radical (OFR) in pulmonary tissue of newborn rats[J];Guangdong Medical Journal;2003-01
4 Tao Li, He Liufang, Dong Lan, et al. Neonatology Department, Guangzhou Children's Hospital, Guangzhou 510120;THE expression of HIF-1α protein in HUVECs injured by hypothermia-hypoxia/ rewarming -reoxygenation[J];Guangdong Medical Journal;2005-09
5 TAO Li, CHEN Ke-zheng (Department of Neonatoloy, Affiliated Children Hospital, Guangzhou Medical College, Guangzhou 510120,China);Expression of HIF-1α Protein in Pulmonary Tissue of Newborn Rats with Pulmonary Hemorrhage Induced by Hypothermia-hypoxia[J];Academic Journal of Guangzhou Medical College;2004-03
6 WANG Wei,CHEN Kezheng,CHEN Guanghua,et al.Department of Neonatal Intensive Care Unit,Guangzhou Children's Hospital,Guangzhou 510120,China.;The levels and expressions of ET-1 and CGRP in the hemorrhagic lung tissue in newborn rats[J];Journal of Emergency Medicine;2003-05
7 CHEN Yu-jun1,LIU Tang-wei2,CHEN Ke-zheng3,PANG Yu-sheng1(1.Pediatric Intensive Care Unit,The First Affi- liated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;2.Department of Cardiology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;3.Neonatal Intensive Care Unit,Guangzhou Children’s Hospital,Guangzhou 510120,Guangdong,China);mRNA expression and the role of preproendothelin-1 in lungs of newborn rats with pulmonary hemorrhage[J];Journal of Clinical Pediatrics;2007-10
Chinese Journal Full-text Database 6 Hits
1 FENG Ying-kai, XU Jian-cheng, YANG Qing-hua, et al. (Institute of Respiratory Disease of PLA,400037,China);Apoptosis of Th1, Th2 cells and its effects in lipopolysaccharide-induced acute lung injury in rats[J];Chongqing Medical Journal;2005-01
2 SUN Hai chen, QIAN Xiao ming, WU Xue hao, et al. (Emergency Center, Nanjing Jinling Hospital, Nanjing 210002);Effects of endotoxin on macrophage apoptosis and MHC Ⅱ expression in traumatized mice[J];Journal of Traumatic Surgery;2001-04
3 ZHU Zhong-quan, FAN Shi-zhi, LI Zhi-ping, et al(Department of Cardiovascular Surgery, Research Institute of Field Battle Surgery, Daping Hospital ,Third Military Medical University, Chongqing 400032, Sichuan,China);Clinical Study on Effects of PGE_1 in Pulmonary Leukocyte Sequestration[J];Journal of Elinical Research;2004-12
4 WANG De-ming,LONG Hong-jie,XU Jin-da,et al (The 2nd Affiliated Hospital of Nanhua University,Hengyang, Hunan 421001, China);Effect of Prostaglandin E_1 on Oleic Acid-induced Acute Lung Injury in Canine[J];Journal of Nanhua University(Medical Edition);2003-03
5 LI Li,FANG Qiang,HE Feifang.Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China;Modulatory effects of prostaglandin E1 on expression of NF-κB in acute lung injury[J];Chinese Journal of Emergency Medicine;2006-04
6 ZHONG Hong-xing 1, HAN Hui 2, ZHANG Yong-shang 2 (1. Dept. of Urology, First Affiliated Hospital of Medical college, Jinan University, Guangzhou 510630, China 2. Dept. of Urology, Tonji Hospital, Tonji Mecidal University, Wuhan 430030,China);Expression of Fas, FasL, Bcl-2 and Bax in acute cardiac allograft rejection in rats[J];Journal of Jinan University(Natural Science & Medicine Edition);2002-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 WANG Quan-xi SHAO Liang-ping LIN Shu-gen LI Guo-ping(College of Animal Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China);Effects of Dietary Zinc Levels on the Cell Apoptosis and the Expression of Fas in the Immune Organ of Young Muscovy Duck[J];Chinese Journal of Animal Nutrition;2008-05
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