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《Chinese Journal of Child Health Care》 2005-03
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Changes in apoptosis and Fas/FasL expression in newborn rats with acute lung injury.

LV Hui, WAN Gen-ping, CHEN Ke-zheng, HUANG Xiao-hong. (Department of Neonatology, the Children Hospital of Guangzhou,Guangzhou, Guangdong 510120, China)  
【Objective】To observe the expression of apoptosis related gene Fas/FasL on lung injury caused by hypoxia and inhaled 100% O_2 after hypoxia. Two lung injury rat models were established by hypoxia or inhaled 100% O_2 respectively. Apoptosis of the lung tissue was observed with the methods of Tunel and in situ hybridization. mRNA expression of Fas/FasL was detected by SqRt-PCR. Apoptosis of rat pulmonary alveolar epithelial cells and pneumoangiogram endothelial cells appeared after 4 hours in two groups. And the index of apoptosis increased with the time passing by ( P =0.003, 0.005 respectively). And expression of Fas/FasL mRNA was up-regulated in two groups, which in inhaled pure oxygen group was higher than in hypoxia group. [Conclusion] Apoptosis and upregulated Fas/FasL mRNA plays an important role on lung injury which is caused by hypoxia or inhaled pure oxygen after hypoxia.
【Fund】: 广东省医学科研基金项目(A2002597);; 广州医学院科研基金项目(01 k 06)
【CateGory Index】: R563
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Ke Zheng, WANG WeiDepartment of Neonatology, Guangzhou Children's Hospital, Guangzhou 510120, China;Pulmonary Hemorrhage Model of Neonatal Rats and Its Clinical Significance[J];Chinese Journal of Contemporary Pediatrics;2002-05
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 HE Liu-Fang, CHEN Ke-Zheng. Department of Neonatal Intensive Care Unit, Guangzhou Children′s Hospital, Guangzhou 510120,China;The construction and identification of siRNA expression vector against hypoxia inducible factor-1α in vitro[J];Chinese Journal of Contemporary Pediatrics;2008-01
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3 Chen Kezheng, Wang Wei, Lu Hui. Department of Neonatology, Guangzhou Children's Hospital, Guangzhou 510120;The relationship between endothelin-1(ET-1), calcitonin gene related peptide(CGRP) and oxygenic free radical (OFR) in pulmonary tissue of newborn rats[J];Guangdong Medical Journal;2003-01
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【Co-references】
Chinese Journal Full-text Database 6 Hits
1 FENG Ying-kai, XU Jian-cheng, YANG Qing-hua, et al. (Institute of Respiratory Disease of PLA,400037,China);Apoptosis of Th1, Th2 cells and its effects in lipopolysaccharide-induced acute lung injury in rats[J];Chongqing Medical Journal;2005-01
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【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 WANG Quan-xi SHAO Liang-ping LIN Shu-gen LI Guo-ping(College of Animal Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China);Effects of Dietary Zinc Levels on the Cell Apoptosis and the Expression of Fas in the Immune Organ of Young Muscovy Duck[J];Chinese Journal of Animal Nutrition;2008-05
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