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The clinicopathologic significance of expression of mtp53, p16 and Bcl -2 protein in lung cancer

Zhang Li, Li Yingzhen. Department of Pulmonary Diseases, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, P.R.China  
Objective To explore the relationship between abnormal expression of mtp53, p16 and Bcl 2 protein and oncogenesis and development of lung cancer.Methods Expression of mtp53, p16 and Bcl 2 protein was detected in 114 lung cancer tissues by immunohistochemistry, and 14 normal lung tissues as control. Results Overexpression of mtp53 protein was not related to pathological type and histological grade of lung cancer (P0.05),but correlated with lymph node status (P0.05). Positive expression of p16 was closely related to histological grade of lung cancer and lymph node metatasis (P0.05),but not to pathological type (P0.05). The positive rate of Bcl 2 protein expression in SCLC was significantly higher than that in NSCLC (P0.05).Conclusion mtp53, p16 and Bcl 2 genes may play important roles in the oncogenesis and development of lung cancer.
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