Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF LUNG CANCER》 2000-04
Add to Favorite Get Latest Update

A study on transcript abnormalities of FHIT gene in human non small cell lung cancer

CHEN Jun, ZHOU Qinghua, QIN Yang, SUN Zhilin, SUN Zefang, WANG Yun, LI Lu, QIN Jianjun. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China  
Objective To explore the role of abnormalities in RNA transcript of FHIT gene in human non small cell lung cancer(NSCLC). Methods Transcript abnormalities of FHIT gene were detected in 35 cancer samples and their corresponding paracancer tissues and normal tissues, four lung cancer cell lines, and 10 lung tissues of benign pulmonary lesions as control by nested RT PCR. Results Fourteen of 35 cancer tissues (40%) had abnormalities in RNA transcripts of FHIT. There were 5 paracancer tissues with transcript abnormalities of FHIT gene out of the 14 lung cancers with transcript abnormalities of FHIT gene, with an abnormality rate of 35.71%. All of 4 lung cancer cell lines had transcript abnormalities of FHIT gene. The aberrant rate of FHIT gene in squamous cell carcinoma tissues (58.82%) was significantly higher than that in adenocarcinoma tissues (22.22%) (P0.05). No relationship was found among the transcript abnormality of the FHIT gene and differentiated degree of the tumor cell, stages of the cancer, size of the primary tumor, location of cancer, and age of the patients (P0.05). Conclusion The results show that there are transcript abnormalities of FHIT gene in NSCLC. FHIT transcript abnormality preferentially occur in squamous cell carcinomas, and it might be the early molecular phenomenon of lung cancer.
【Fund】: 国家自然科学基金!(39870 2 99);; 国家教委博士点基金!(9849)资助 &&
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 6 Hits
1 ZHOU Qinghua, CHEN Jun, QIN Yang, SUN Zhilin, LIU Lunxu, SUN Zefang, CHE Guowei, LI Lu, Qin Jianjun, GONG Youling. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R;A study on the allelic deletion and mutation of FHIT gene in human non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2001-01
2 WANG Yun, ZHOU Qinghua, ZHANG Shangfu, CHENG Liang, LIU Lunxu, LI Lu, WU Zhu, CHE Guowei, QIN Jianjun. Department of Thoracocardiac Surgery, West China Hopsital, Sichuan University (Former The First University Hospital, West China University of Medical Sc;Reduction of FHIT gene expression in primary lung cancer[J];Chinese Journal of Lung Cancer;2002-01
3 ZHAO Po, LU Yali, ZHONG Mei, CHEN Lezhen. Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, P.R.China;Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer[J];Chinese Journal of Lung Cancer;2002-05
4 WU Hanlin, WANG Yun, ZHOU Qinghua, ZHU Wen, WANG Yanping, CHE Guowei, CHEN Xiaohe, SUN Zhilin. Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Construction and identification of procaryotic expression vector of human NIT1 gene[J];Chinese Journal of Lung Cancer;2005-02
5 WANG Yun 1, ZHOU Qinghua 1, QIN Yang 2, YUAN Shulan 3, SUN Zhilin 2, WANG Yanping 3, CHEN Xiaohe 3, SUN Zefang 2, SONG Yi 3, YANG Yan 1. 1-3 (Department of Thoraco-Cardiac Surgery, West China Hospital, Basic Medical College, Cancer Institute, West China;Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549[J];Chinese Journal of Medical Genetics;2002-03
6 GAO Jin,GUO Yan-yan,Li Xiu-xia.Department of Pediatrics,First Affiliated Hospital,Inner Mongolia Medical College,Huhehaote,Neimenggu,010050,China;The expression of FHIT and the relativity with cigarette in NSCLC[J];Chinese Journal of Primary Medicine and Pharmacy;2006-01
China Proceedings of conference Full-text Database 1 Hits
1 Wu HanLin Wang Yun Zhou QingHua Zhu Wen Wang YanPing Chen GuoWei Chen XiaoHe Sun ZhiLin Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province and Cancer Center,West China Hospitial,Sichuan University,Chengdu,Sichuan 610041,P.R.China.;Construction and identification of eukaryotic expression vectors of human NIT1 gene[A];[C];2007
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Qinghua, CHEN Jun, QIN Yang, SUN Zhilin, LIU Lunxu, SUN Zefang, CHE Guowei, LI Lu, Qin Jianjun, GONG Youling. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R;A study on the allelic deletion and mutation of FHIT gene in human non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2001-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HE Yu jun,HE Shuang wu Department of General Surgery,Deping Hospital and the Research Institute of Surgery, The Third Military Medical College,Chongqing,400042,P.R. China;The relationship between gastrin and PCNA expression in colorectal cancer tissue[J];CHINESE JOURNAL OF CANCER;2000-02
2 DUAN Xiao ming1, ZHANG Gui ying1, CHEN Zhu chu2* , et al. 1. Department of Gastroenterology, Affiliated Xiangya Hospital, Hunan Medical University,Changsha 410008, P.R.China 2. Laboratory of Tumor Cell Biology, Cancer Research Institute, Hunan Me;Abnormal expression of the FHIT gene in human primary colorectal cancer and colorectal cancer cell lines[J];CHINESE JOURNAL OF CANCER;2000-09
3 LIU Fu-Xing1,2,HUANG Xiao-Ping1,ZHAO Chun-Xia1,XU Xin1,HAN Ya-Ling1,CAI Yan1,WU Ren-Liang2,WU Min1,ZHAN Qi-Min1,WANG Ming-Rong1 1.National key Laboratory of Molecular Oncology,Cancer Institute(Hospital),Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,P.R.China 2.Department of Pathology,Tongji Medical College,Huazhong University of Science & Technology,Wuhan,Hubei,430030,P.R.China;Allelic Loss and Down-Regulation of FHIT Gene Expression in Esophageal Squamous Cell Carcinoma[J];Chinese Journal of Cancer;2004-09
4 ;Development of Multislice Helical CT in Chest Disease[J];;2000-03
5 CHEN Jun, ZHOU Qinghua, QIN Yang, SUN Zhilin, SUN Zefang, LIU Lunxu. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu 610041, P.R.China;A study on the allelic deletion of nm23 genes in human lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-01
6 ZHOU Qinghua, CHEN Jun, QIN Yang, SUN Zhilin, LIU Lunxu, SUN Zefang, CHE Guowei, LI Lu, Qin Jianjun, GONG Youling. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R;A study on the allelic deletion and mutation of FHIT gene in human non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2001-01
7 WANG Yun, ZHOU Qinghua, ZHANG Shangfu, CHENG Liang, LIU Lunxu, LI Lu, WU Zhu, CHE Guowei, QIN Jianjun. Department of Thoracocardiac Surgery, West China Hopsital, Sichuan University (Former The First University Hospital, West China University of Medical Sc;Reduction of FHIT gene expression in primary lung cancer[J];Chinese Journal of Lung Cancer;2002-01
8 Ding Huaye, Gao Lanxiang, Deng Yongjiang, et al (Department of Pathology,General Hospital,Beijing Military Area,Beijing 100700 China);THE EXPRESSION OF S100, S100α AND S100β IN BREAST CARCINOMA AND ITS DIAGNOSTIC SIGNIFICANCE[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1999-04
9 LUO Mingyue, SHAN Hong, XU Chuan,et al. Department of Radiology, No.3 Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province P. R. China;Comparison of Multislice CT and Its Postprocessing Techniques in Examination of Trachea and Main Bronchus Neoplasms[J];Journal of Clinical Radiololgy;2005-06
10 CHEN Yuqing,CAI Yingyun, LIU Limin.Department of Pulmonary Medicine, Affiliat ed zhongshan Hospital of Fudan University,Shanghai 200032,China;Clinical significance in diagnosis with measuring the altera tion of p53,K-ras and p16 genes in lung cancer[J];Journal of Clinical Internal Medicine;2003-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WANG Ping1,ZHANG Qing2,WANG Zu-yi2,CHENG Ze-nong1,YU Dong-hong1,WU Shi-wu1(1.Department of Pathology,Bengbu Medical College,Bengbu 233030,Anhui;2.Central Laboratory,Affiliated Hospital of Bengbu Medical College,Bengbu 230004,Anhui,China);Expression of FHIT and p16 in Non-small Cell Lung Cancers[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-03
2 Zhu Li-Qin,Diao Lu-Ming ,Chen De-Ji ,Li Hong -Gang ,Liu Xuan,Zou Zu-Yu,Li Bei-Yun,Wang Min,Liu Ming -QiuDepartment of Pathology,Wuhan University,Wuhan,Hubei,430071,P.R.China;Relationship between hMSH_2 and FHIT Gene Expression in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2003-06
3 WANG Yun, ZHOU Qinghua, ZHANG Shangfu, CHENG Liang, LIU Lunxu, LI Lu, WU Zhu, CHE Guowei, QIN Jianjun. Department of Thoracocardiac Surgery, West China Hopsital, Sichuan University (Former The First University Hospital, West China University of Medical Sc;Reduction of FHIT gene expression in primary lung cancer[J];Chinese Journal of Lung Cancer;2002-01
4 WU Hanlin, WANG Yun, ZHOU Qinghua, ZHU Wen, WANG Yanping, CHE Guowei, CHEN Xiaohe, SUN Zhilin. Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Construction and identification of procaryotic expression vector of human NIT1 gene[J];Chinese Journal of Lung Cancer;2005-02
5 CHANG Xiujun, YANG Sheng, ZHANG Haiqing, WANG Hui, JIANG Ying. Department of Thoracic Surgery, Tuberculosis and Thoracic Tumor Research Institute of Beijing, Beijing 101149, P.R.China;Expression of FHIT gene in precancerous lesions and primary lung cancer tissues[J];Chinese Journal of Lung Cancer;2006-04
6 He Zibiao,Yang Weiming,Jiao Baoting,et al.The Affiliated Hospital of Zunyi Medical College,Zunyi 563003;Establishment of human colon carcinoma implant tumor model in nude mice[J];Guizhou Medical Journal;2007-09
7 ;Fragile histidine traid and early predict of lung cancer[J];Henan Medical Research;2004-03
8 Xia Xing,Yuan Xianhou,Jiang Pucha.Department of Neurosurgery,Zhongnan Hospital of Wuhan University,Wuhan 430071;Expression and significance of FHIT、PTEN in human glioma.[J];Central China Medical Journal;2006-03
9 SHI Shu-zhen,ZHAO Jun-jun,ZHAO Wei-hong,XU Xiao-hui.Department of Oncology,the Third People's Hospital of Dalian,Dalian 116033,China;The expression and clinical significance of FHIT protein and mdm2 protein in non-small cell lung cancer[J];Chinese Clinical Oncology;2009-03
10 YOU Si-hong,LIU Ping*1,ZHANG Dao-fu2,DING Xiao-jian3,ZHANG Xiao-yong(Department of Gastroenterology,1Oncology,3Central Laboratory, the First Affiliated Hospital of NJMU,Nanjing 210029; 2Department of Gastroenterology, Nanjing 81 Hospital, Nanjing 210002, China);Detection and analysis of abnormalities of FHIT gene in gastric cancer[J];Acta Academiae Medicinae Nanjing;2005-04
China Proceedings of conference Full-text Database 1 Hits
1 Wu HanLin Wang Yun Zhou QingHua Zhu Wen Wang YanPing Chen GuoWei Chen XiaoHe Sun ZhiLin Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province and Cancer Center,West China Hospitial,Sichuan University,Chengdu,Sichuan 610041,P.R.China.;Construction and identification of eukaryotic expression vectors of human NIT1 gene[A];[C];2007
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved