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《Chinese Journal of Lung Cancer》 2001-05
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Clinical and prognostic significance of serum CEA, NSE, CYFRA211, CA125 and CA199 levels in patients with advanced non-small cell lung cancer

WU Meina, LIU Xuyi, FANG Jian, AN Tongtong, WANG Jie. Beijing Cancer Hospital, Beijing 100036, P.R.China  
Objective To judge clinical and prognostic values of serum CEA, NSE, CYFRA211, CA125 and CA199 levels in patients with advanced non small cell lung cancer (NSCLC). Methods Ninety five untreated but confirmed by histology or cytology patients with advanced NSCLC were studied. The serum levels of CEA, NSE, CYFRA211, CA125 and CA199 were detected before and after treatment by cisplatin based regimens. Results The positive rate was 53.7% , 70.5%, 62.2%, 54.1% and 31.6% for CEA, NSE, CYFRA211, CA125, CA199 respectively, before treatment. The significant decreases of the markers were observed in 39 partial response patients (P=0.030, 0.000, 0.009, 0.002, 0.034 respectively). The overall 1 and 2 year survival rate were 52.7%(50/95) and 14.7%(14/95) respectively. Cox proportional hazard multivariate analysis showed that the prognosis of advanced NSCLC patients was related to response rate of first cycle, staging, performance status and serum CYFAR211 level before treatment, but not to histology and serum levels of CEA, NSE, CA125 and CA199 before treatment. Conclusion The decrease in CEA, NSE, CYFRA211, CA125, and CA199 levels could be used to evaluate the chemotherapeutic response. TNM stage and performance status and CYFRA211 before treatment can be used as prognostic parameters in patients with advanced NSCLC.
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 10 Hits
1 GUO Zhanlin, QIU Lin, ZHANG Fengkun, YANG Fude, ZHAO Long, ZHANG Yulong, ZHU Xianming, QIU Nengyong. Department of Cardiothoracic Surgery, First Affiliated Hospital of Inner Mongulia Medical College, Huhhot, Inner Mongulia 010059, P.R.China.;Diagnostic and prognostic values of serum CA125, NSE, CT levels in patients with lung cancer[J];Chinese Journal of Lung Cancer;2003-03
2 WU Guangping , BA Jing, WANG Enhua, TENG Yuee, FAN Xia. Pathological Diagnosis Center, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R.China;Diagnostic value of determination of CEA, CA125, CA153 and CA199 assay in pleural fluid for lung cancer[J];Chinese Journal of Lung Cancer;2004-01
3 Wang Qingmin1,Chen Chuangang2(1.Department of Radiotherapy,Qingdao Tumor Hospital;2.Department of Laboratory,Qingdao 266042,China);Clinical Significance of TSGF and CEA in the Treatment of Patients with Advanced Breast Cancer[J];Journal of Basic and Clinical Oncology;2010-02
4 PU Dan,LI Wei-min,WU Di,et al.(Department of Pulmonary Medicine,West China University Hospital,Sichuan University,Chengdu 610041,China);Evaluation of Safety and Efficacy of Gefitinib('Iressa',Zd1839)as a Treatment for Advanced Non-Small-Cell Lung Cancer[J];West China Medical Journal;2006-03
5 Chen Qin Jin Xianqiao Li Qun , et al The Department of Respiratory DiseasesThe 1st Affiliated People’s Hospital of Shanghai, Jiaotong University, Shanghai 200080;Initial Investigation of Tumor Markers Changing in Chemotherapeutics among Lung Cancer Patients[J];Journal of Clinical Pulmonary Medicine;2003-06
6 HE Ze-lai,WANG Huo-qiang,LIAO Gui-dong,PAN Hui-zhong,WU Ji-yong.Department of Nuclear Medicine,Pulmonary Hospital of Shanghai,Shanghai 200433,China;Clinical significance of serum CEA and CYFRA21-1 levels in patients with lung cancer metastasis or postoperative relapse[J];Journal of Clinical Pulmonary Medicine;2010-02
7 YANG Qiong1,ZHU Hui-rong2,YAN Hai-xia1,ZHAO Li-hong3 (1. School of Basic Medical Sciences,Shanghai University of TCM,Shanghai 201203,China; 2. Department of Oncology,Shuguang Hospital,Shanghai University of TCM,Shanghai 201203,China; 3. Department of Oncology,Longhua Hospital,Shanghai University of TCM,Shanghai 200032,China);Typical Correlation Analysis of TCM Pulse Figure Character Parameters and Cancer Index in Primary Lung Cancer Patients[J];Liaoning Journal of Traditional Chinese Medicine;2011-01
8 JIA Jing,MA Hong-jie,ZHANG Jian-peng Department of Respiratory Disease,General Hospital of the Chinese Peoples Armed Police Force Beijing 100039,China.;The role of combination detections of five tumor markers in diagnosis for lung cancer[J];Journal of Modern Oncology;2008-10
9 LI Pei1, GU Yue_qing2, YU Fang_zhi2,et al.(1.Xujiahui Regional Hospital of Shanghai,Shanghai 200030,China;2.Shanghai Chest Hospital ,Shanghai 200030,China);The Impact of Chemotherapy on Serum Tumor Markers and Nitrogen Monoxide in Patients with Non-small Cell Lung Cancer[J];Zhejiang Cancer Journal;2002-04
10 AO Jin-e,YANG Wan(Department of Pathology,The First Hospital of Jingmen City,Jingmen 448000,China);The clinic significance of TSGF,CEA in non-small-cell lung cancer[J];China Medical Herald;2007-16
【Citations】
Chinese Journal Full-text Database 1 Hits
1 HU Yanping, ZHONG Aijun, YANG Xiaoling, et al. Hubei Cancer Hospital, Wuhan 430079, China;Prognostic value of serum CA125 level in patients with advanced non-small cell lung cancer[J];CHINESE JOURNAL OF ONCOLOGY;2000-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Xu Mei Lin1, Wu Bing Quan2, Zhong Hao Hao2, Yang Xia1, Heng Wan Jie2 1.Department of Pathology, Tianjin Chest Hospital, Tianjin,300051, P.R.China 2.Department of Pathology, School of Medicine, Beijing University, Beijing,100083, P.R.China;Diagnosis of Lymph Node Micrometastases in Human Lung Carcinoma: Determination of p53 Gene Mutations by Polymerase Chain Reaction Temperature Gradient Gel Electrophoresis (PCR-TGGE)[J];Chinese Journal of Cancer;2004-07
2 MA Hu,BAI Yu-ju,LI Ning,et al.(Department of Cancer,Affiliated Hospital,Zunyi Medical College,Zunyi 563000,China);Significance of combined determination of vascular endothelial growth factor,CA125 and carcinoembryanic antigen in peripheral blood of patients with non-small cell lung cancer[J];Chongqing Medicine;2010-04
3 FAN Shi zhi, CHEN Jian ming, LI Zhi ping, NIU Hui jun, LIAO Xiang li, LEI Jun (Department of Thoracic and Cardiovascular Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Esophageal carcinoma resection and gastroesophageal reconstruction under left heart bypass[J];Acta Academiae Medicine Militaris Tertiae;2001-05
4 WANG Yun, LIU Lunxu, YANG Junjie, CHEN Jun, ZHAO Yongfan, WU Zhu, CHE Guowei, HE Jintao, QIN Jianjun, ZHOU Qinghua. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu 610041, P.R.China;Risky factors of post operative respiratory failure in patients with lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-01
5 CHE Guowei, ZHOU Qinghua, ZHANG Shangfu, LIU Lunxu, CHEN Jun, CHENG Niang, QIN Jianjun, LI Lu. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China;Detection of micro-vascular density(MVD) and its clinical significance in lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-04
6 SHEN Cheng,FAN Shizhi,JIANG Yaoguang,CHEN Jianmin, LI Zhiping. Department of Thoracocardiac Surgery, Daping Hospital, Third Military Medical University, Chongqing 400038,P.R.China;Effects of vascular endothelial growth factor in the invasion and metastasis of non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2001-02
7 LI Guoren, DAI Jianhua, WANG Yanqing, CHEN Guanghui, LIU Xiaofeng, MIAO Fulu, Bai Ling, CHEN Yulin. Department of Chest Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R.China;Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues[J];Chinese Journal of Lung Cancer;2002-01
8 HE Jintao, ZHOU Qinghua, YUAN Shulan, WANG Yanping, CHEN Xiaohe, QIN Jianjun. Department of Thoracocardiovasc Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;The growth-inhibiting effect and its molecular mechanism of Tanshinone on human lung cancer cell line in vitro[J];Chinese Journal of Lung Cancer;2002-02
9 LU Yanrong, LIN Ping, ZHANG Jie, WANG Xiujie, HUANG Xiaozhong, NING Qizhi. Institute of Cancer Research, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Establishment and characteristics of multidrug-resistant Lewis lung cancer cell line[J];Chinese Journal of Lung Cancer;2002-03
10 GAN Chongzhi, CONG Wei. Department of Thoracic Surgery, Sichuan Provincial Hospital, Chengdu, Sichuan 610072, P.R.China;Study on pulmonary artery infusion following lobectomy in patients with lung cancer[J];Chinese Journal of Lung Cancer;2002-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zhang Changwu, Zheng Xiangdong, Pan Guixia, et al Department of Oncology, Tongcheng People's Hospital, Tongcheng 231400;Clinical observation of weekly dose of paclitaxel,cisplatin combined with fluorouracil therapy with advanced gastric cancer[J];Anhui Medical Journal;2009-02
2 BU Li-jia,DU Ying-ying,PAN Yue-yin,XIONG Fu-xing,GU Kang-sheng(Department of Oncology,The First Affiliated Hospital to Anhui Medical University,Hefei,Anhui 230022);Irinotecan combined with capecitabine in line-2 treatment of locally advanced or metastatic gastric cancer[J];Anhui Medical and Pharmaceutical Journal;2009-05
3 Luo Suxia Chen Xiaobing Xiao YijunDepartment of Medical Oncology,Henan Provincial Cancer Hospital,Zhengzhou 450008,China;Serum tumor biomarkers associated with lung cancer[J];Oncology Progress;2005-03
4 Fan Yaguang1 Qiao Youlin2#1 Institute of Radiomedicinc,CAMS,Tianjin 300192,China2 Institute of Oncology,CAMS,Beijing 100021,China;Lung cancer screening[J];Oncology Progress;2007-01
5 LU Han-kui, JI Hong, ZHU Rui-sen, et al. (Department of Nuclear Medicine, Shanghai Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China);Comparative Study Between Bio-chip Detection and Chemiluminescent Immunoassay for Multi-tumor Markers[J];Labeled Immunoassays and Clinical Medicine;2005-02
6 CHEN Wu,SUN Yan-li,XI Yan(Dept.of Nuclear Medicine,Jilin Provincial Cancer Hospital,Changchun 130012,China);Correlation Between Serum Tumor Marker Level and Stage,Therapeutic Response and Survival in Patients with Lung Cancer[J];Labeled Immunoassays and Clinical Medicine;2008-04
7 LU Jun-yan,TAN Ai-guo,JIANG Zhi-gang.Department of Clinical laboratory,Beijing Hospital Beijing 100730,China;The Study on the Serum Tumor Markers Used to Diagnose Lung Cancer[J];Journal of Chinese Physician;2001-11
8 ZHANG Lu-Min, ZHAO Wei, LIU Guo-JinDepartment of Thoracic Surgery, First Clinical Hospital, Jilin University, Changchun 130021, China;Expressions of CEA and CA153 in the serum of breast cancer patients and their clinical significances[J];Journal of the Fourth Military Medical University;2007-04
9 GUO Zhanlin, QIU Lin, ZHANG Fengkun, YANG Fude, ZHAO Long, ZHANG Yulong, ZHU Xianming, QIU Nengyong. Department of Cardiothoracic Surgery, First Affiliated Hospital of Inner Mongulia Medical College, Huhhot, Inner Mongulia 010059, P.R.China.;Diagnostic and prognostic values of serum CA125, NSE, CT levels in patients with lung cancer[J];Chinese Journal of Lung Cancer;2003-03
10 WU Guangping , BA Jing, WANG Enhua, TENG Yuee, FAN Xia. Pathological Diagnosis Center, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R.China;Diagnostic value of determination of CEA, CA125, CA153 and CA199 assay in pleural fluid for lung cancer[J];Chinese Journal of Lung Cancer;2004-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Xu Chunhua Yu Like Zhang Yu Department of Respiratory Medicine,Nanjing Chest Hospital,Nanjing 210029,China;The diagnostic value of tumor M_2 pyruvate kinase in malignant pleural effusion[J];Oncology Progress;2011-02
2 WANG LIN,CHEN HE-YI,YAN YING(Department of Laboratory Test,The Affiliated Hospital Qingdao University Medical College,Qingdao 266003,China);REASONABLE UTILIZATION OF TUMOR MARKERS IN THE DIAGNOSIS OF LUNG CANCERS[J];Acta Academiae Medicinae Qingdao Universitatis;2008-02
3 ZHANG Ai-min,ZHANG Peng (Department of Laboratory Test,the Affiliated Cancer Institute and Hospital,Tianjin Medical University,Tianjin 300060,China);Clinical Significance of Serum Calcitonin and Correlative Tumor Markers in the Diagnosis and Therapy of Lung Cancer[J];Labeled Immunoassays and Clinical Medicine;2007-03
4 HUANG Qiao-ming1,GE Ming-jian1,LUO Peng2(1.Department of Thoracic Surgery;2.Department of Clinical Labortory,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Value of multi-tumor markers protein biochip detective system in diagnosis and typing of non-small cell lung cancer[J];Chongqing Medicine;2010-15
5 ZHANG Peng,WANG Guoshen,MA Shanshan,KONG Weihui,ZHU Hongjing,ZHAO Zili,LI Zhihui.Department of Nuclear Medicine,Huaihe Hospital Affiliated to Henan University,Kaifeng 475001,China;Joint detection of serum CEA and CA125 to early differential diagnose of lung cancer and pneumonia[J];Clinical Medicine;2010-11
6 WU Guangping , BA Jing, WANG Enhua, TENG Yuee, FAN Xia. Pathological Diagnosis Center, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R.China;Diagnostic value of determination of CEA, CA125, CA153 and CA199 assay in pleural fluid for lung cancer[J];Chinese Journal of Lung Cancer;2004-01
7 LIU Yunqiu, YU Liqun, LIN Jiangtao. *Department of Respiratory Diseases, Affiliated Kailuan Hospital, Huabei Coal Medical School, Tangshan, Hebei 063000, P.R.China;Study on the value of tumor markers ProGRP, CYFRA21-1, NSE and CEA in the differential diagnosis of pleural effusion[J];Chinese Journal of Lung Cancer;2006-03
8 ZOU Dawei, ZHANG Bin, BA Jing, YE Qianhong, WU Guangping. Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R.China;Expression and significance of CEA and CA153 in pleural fluid of patients with lung cancer[J];Chinese Journal of Lung Cancer;2006-04
9 Yu Hao,He Xiaojiang,Qu Yuejin,et al.The First Hospital of Xiamen,Xiamen 361003,China;Combined assay with serum tumor markers of CEA,CYFRA21-1,CA50,CA19-9,CA125 for lung cancer diagnosis[J];Fujian Medical Journal;2004-05
10 Li Jian-gang,Ji Zhi-gu,Cui Xue-jun,et al.Department of Nuclear Medicine,Nantong Tumor Hospital,Nantong (226361),China;Clinical Value of Combined Detection of Tumor Markers in Effusion Fluid for Diagnosis of Malignant Pleural Effusion and Ascites[J];Journal of Radioimmunology;2010-02
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