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Analysis of the familial risk factors on lung cancer

JIN Yongtang , HE Xingzhou, ZHOU Xiaotie. Department of Environmental Health, Anhui Medical University, Hefei, Anhui 230032, P.R.China  
Objective To study the familial risk factors on lung cancer and the effect of genetic factors on lung cancer. Methods With methods of genetic epidemiology, 370 probands of lung cancer and 370 spouses of the probands (control) were studied. Results The risk of the probands' relatives was 1.85 times higher than that of their spouses' relatives (P0.01). Compared with the spouses' parents and female relatives, the OR of the probands' parents and female relatives was 2.66 and 2.64 (P 0.01), respectively. Compard with the female controls' parents, the OR of female probands' parents was 2.27 (P0.01). Conclusion The susceptibility of the probands' relatives with lung cancer is higher than that of their spouses' relatives. The genetic factor is one of risk factors on lung cancer.
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