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《Chinese Journal of Lung Cancer》 2002-04
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Expression and clinical significance of nm23-H1 and CD44v6 in non-small cell lung cancer

WANG Zitong, ZHANG Haiqing, LI Shiye. Department of Thoracic Surgery, Beijing Thoracic tumour and Tuberculosis Hospital, Beijing 101149, P.R.China  
Objective To study the role of nm23 H1 and CD44v6 gene in non small cell lung cancer (NSCLC). Methods Expressions of nm23 H1 and CD44v6 genes were analyzed in 147 cases of NSCLC by SP immunohistochemistry method. Results The overall positive rate of nm23 H1 staining was 62.6% (92/147). Significant differences in the positive rate of nm23 H1 were found between well and poor differentiated groups [68.6% (83/121) [WTBX]vs 34.6% (9/26)], and between adenocarcinoma and squamous cell carcinoma , and between adenocarcinoma and squamous cell carcinoma [78.8% (52/66) [WTBX]vs 50.8% (32/63) ] ( (P0.05), but not between stage Ⅰ+Ⅱ and stage Ⅲ+Ⅳ [ 65.3% (62/95) [WTBX]vs 57.7% (30/52) ], and between N0 and N1 3 , and between N0 and N1 3 [64.7% (55/85) [WTBX]vs 59.7% (37/62) ]( ( P0.05). The positive rate of nm23 H1 of patients who survived for more than 3 years was 71.4% (55/77), which was significantly higher than 52.9% (37/70) of patients who survived for less than 3 years (χ 2=5.4, P0.05). For CD44v6, the overall positive rate was 63.9% (94/147). Significant differences in the positive rate of CD44v6 were found between well and poor differentiated groups [68.6% (83/121) [WTBX]vs 42.3% (11/26)], and between adenocarcinoma and squamous cell carcinoma , and between adenocarcinoma and squamous cell carcinoma [53.0% (35/66) [WTBX]vs 77.8% (49/63) ] ( (P0.05), but not between stage Ⅰ+Ⅱ and stage Ⅲ+Ⅳ [ 66.3% (63/95) [WTBX]vs 59.6% (31/52) ], and between N0 and N1 3 , and between N0 and N1 3 [63.5% (54/85) [WTBX]vs 64.5% (40/62) ]((P0.05). The positive rate of CD44v6 of patients who survived for more than 3 years was much lower than that of patients who survived for less than 3 years (43/74 vs 51/70, P 0.01 ). The 3 year survival rate in patients with nm23 H1(+)CD4v6(-) was significantly higher than those with nm23 H1(-)CV44v6(+) (22/32 vs 11/34, P0.01). Conclusion There are some relationships among expressions of nm23 H1 and CD44v6 in NSCLC and cell differentiation, histological classification and prognosis, and no relation in stage and lymph node metastasis.
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 8 Hits
1 ZHANG Lin, MENG Long, WANG Lei, PENG Zhongming, CHEN Jinhan, WANG Zhou. Shandong Provincial Hospital, Jinan, Shangdong 250021, P.R.China;The clinical significance of detection of vascular endothelial growth factor and CD44v6 expression in human non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2004-05
2 WEI Ming-chao1,YUE Shi-chang1,WANG Qi-min2,WANG Nai-yu2 (1.Department of Chest Surgery,2.Department of Pathology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China);Relation of NM23-H1 and CD44v6 expression to patient's prognosis in the non-small cell lung cancer without lymph node metastasis[J];Journal of Dalian Medical University;2011-05
3 YAN Hai-jun1,CHEN Ming-wei2(1.Department of Respiratory of Medicine,Affiliated 1st Hospital,Nanjing Medical University,Nanjing 210006,China;2.Department of Respiratory of Medicine,the First Hospital of Xi'an Jiaotong University,Xi'an 710061,China);Study on the expression of nm23 and its clinical significance in lung neoplasms[J];Journal of Southeast University(Medical Science Edition);2009-04
4 Chen Yuxia1,Wang Yifei2.(1.Department of Biotechnology,Jinan University,Guangzhou 510632;2.Jinan University Biomedicine Research & Development center,Guangzhou 510632);Recent advances in nm23 genes and lung cancer[J];Chinese Journal of Health Laboratory Technology;2004-01
5 FENG Li1,HUA Bao-jin2,PIAO Bing-kui2,WANG Fang1(1 Department of Oncology,Wangjing Hospital Affiliated to China Science Academyof Traditional Chinese Medicine,Beijing 100102,China;2 Department of Oncology,GuanganmenHospital Affiliated to China Science Academy of Traditional Chinese Medicine,Beijing 100053,China);Expression of CD_(44)V6 and CD_(49) in Lewis mice lung carcinoma cells by Feiliuping Ⅱ[J];Chinese Journal of New Drugs;2007-01
6 FENG Li~1 HUA Bao-jin~2 PIAO Bing-kui~2 1 Department of Oncology,Wangjing Hospital Affiliated to China Science Academy of Traditional Chinese Medicine,Beijing 100102,China; 2 Department of Oncology,Guang An Men Hospital Affiliated to China Science Academy of Traditional Chinese Medicine,Beijing 100053,China;Modulation of CD_(44)v6 and CD_(49) expression by FeiliupingⅡfor patients with non-small cell lung cancer[J];Chinese Journal of New Drugs;2007-09
7 AERXIDING·Patiguli,ZHANG Guo-qing,MA Ling (First Department of Medical Onology,Tumor Hospital,Xinjiang Medical University,Urumqi 830011,China);The expressions of nm-23 and CD44v6 protein in non-small cell lung cancer and their clinical significance[J];Tumor;2008-07
8 WEI Zhuxin1,LI Ping2,WANG Rensheng1,GAN Langge1,GAN Mei1 1.Department of Radiotherapy,the First Affiliated Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530021,China;2.Department of Pathology,the First Affiliated Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning 530021,China;Expression and significance of Ki67 and nm23 gene in nasopharyngeal carcinoma[J];China Medical Herald;2011-22
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Chen Xiaofeng, Zhou Qinghua, Shi Yingkang, et al. Department of Thoracocardiac Surgery, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;The expression of nm23-H_1 gene product and its relationship with prognosis in patients with non-small cell lung cancer[J];Chinese Journal of Experimental Surgery;1998-06
2 Dei wen- dong, Zhang Ru-gang, Yan Shui-zhong,et al Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021;NDPK/nm23 EXPRESSION AND ITS CORRELATION WITH LYMPH NODE METASTASIS IN HUMAN LUNG CANCER[J];CHINESE JOURNAL OF ONCOLOGY;1994-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Xiaoyin,Shen Zhuoqun (Departmant of TCM,Medical College of Jin'an University,Guangzhou 510632,China);EFFECTS OF QIONGYUGAO ON THE EXPRESSION OF NM23 AND PCNA OF EXPERIMENTAL LUNG CANCER MICE TREATED BY CHEMOTHERAPY[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-02
2 CHE Guo-Wei, ZHOU Qing-Hua, ZHU Wen, WANG Yan-Ping, QIN Yang, LIU Lun-Xu, CHEN Xiao-He, SUN Yi-Lin, SUN Ze-FangSichuan Provincial Key Laboratory of Lung Cancer Molecular Biology, West China Hospital,Sichuan University, Chengdu, Sichuan, 610041, P.R.China.;Molecular Mechanism of Reversing Metastatic Phenotype in Human High-metastatic Large Cell Lung Cancer Cell Line L9981 by nm23-H1[J];Chinese Journal of Cancer;2005-03
3 Song Bo,Tang Jianwu,Du Yue,et al Department of Pathology,Dalian Medical University;Significance of nm23/NDPK Expression in Bronchiolo-Alveolar Carcinoma[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1999-03
4 Yu Zhenkun; Wang Tianduo; Li Xuezhong(From the Department of Otolaryngology, Affiliated Hospital of Shandong Medical Uni-versity, Jinan 250012 );nm23 gene product/NDPK expression and its clinical significance in laryngeal and hypopharyngeal carcinoma[J];;1997-03
5 YU Qiuju, MA Lan, JING Shibing, XU Yanli, GENG Dan. Liaoning Provincial Hospital, Shengyang, Liaoning 110015, P.R.China;Clinic significance of nm23, collage Ⅳ and PCNA expression in non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2001-06
6 WANG Haifeng, CHEN Xiaofeng, GAO Wen, DING Jiaan, YI Xianghua. Department of Thoracic Surgery, Shanghai Pneumology Hospital, Shanghai 200433, P.R.China;PCR-SSCP analysis of nm23 gene mutation in non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2002-03
7 ZHENG Haixia, ZHOU Qinghua, SUN Zhilin, Qin Yang, ZHU Wen, WANG Yanping, SUN Zefang, CHE Guowei. Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;Regulation of nm23-H_1 transfection on expression of integrins in human high-metastasis large cell lung cancer cell line L9981[J];Chinese Journal of Lung Cancer;2004-02
8 Zhang Gang Tang Shaoming Liang Jie,et al (Instituts of Plastic Surgery,Guangdong Medical College,Zhanjiang 524001);Expression of nm23 and p53 proteins in skin cancer and its clinical significance[J];JOURNAL OF GUANGDONG MEDICAL COLLEGE;1999-04
9 GU Huaping 1, Liu Yanru, NI Canrong ( 1 PLA 251st Hospital,Zhangjiakou 075000, China) \;〔;CLINICAL SIGNIFICANCE OF THE EXPRESSION OF CD44v6 AND NM23H1 GENES IN LUNG CANCER TISSUE[J];Chinese Journal of Histochemistry and Cytochemistry;2002-01
10 CHEN Tian-xing,LI Lin,CHEN Jian-wei.Department of Pathology,the First People′s Hospital of Yunnan Province,Kunming 650032,China;The expression of C-erbB-2 and nm23 in primary breast cancer and its relation to lymphogenous matastasis[J];;2004-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SHAO Xiao-hua 1,GAO Yu-feng 2,LI Xu 2,YU Xin-zhi 2,ZHOU Qing 3,WANG Yuan 3 (1.Dept of Laboratory Medicine,The Second People Hospital of Hefei,Hefei 230011;2.Dept of Infection Medicine,First Affiliated Hospital of Anhui Medical University,Hefei 230022;3.Laboratory of Molecular Biology of Anhui Medical University,Hefei 230032,China);Expression of CD44v6 in primary hepatic carcinoma and its clinical signifance[J];Anhui Medical and Pharmaceutical Journal;2005-03
2 Yang Rui yi, Zhang Mei ying, Zhao Li gan Bioengineering Research Institute, Jinan University, Guangzhou, 510632, P R China;nm23-H_1 gene induces apoptosis and improves the antioxidation in tumor cell[J];CHINESE JOURNAL OF CANCER;2000-05
3 ZHU Zhi-Hua1, RONG Tie-Hua1, ZENG Can-Guang1, WU Qiu-Liang2, MA Yun3, HUANG Xiao-Ping1, LI Bao-Jiang1, ZHANG Peng-Yuan1, ZHAO Jin-Ming1, HU Wei1, ZHANG Shi-Yi1, YU Hui1, MA Guo-Wei1, ZHANG Lan-Jun1, WEN Zhe-Sheng1, FU Jian-Hua1, LONG Hao1 1. Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China 2. Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China 3. Center of Experimental Animal, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P.R.China;Vascular Endothelial Growth Factor Expression and Microvessel Density in StageⅠ-Ⅱ Non-small Cell Lung Cancer and Their Prognostic Significances[J];Chinese Journal of Cancer;2005-07
4 WENG Mi-Xia1, WU Cui-Huan2, YANG Xiu-Ping1 1. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China 2. Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Expression and Significance of E-cadherin, CD44v6, and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2008-02
5 Han Zhenguo 1,Wang Tie 2,Ma Changjin 1 (1\ The Third Clinical College,Norman Bethune University of Medical Sciences, Changchun;2 The Second Hospital of Yingkou,Liao Ning);The expression of β1 integrin and focal adhesion kinase P 125FAK on human lung cancer cell lines[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1999-01
6 ZHANG Hanhan Department of Biochemistry,Binzhou Medical University,Yantai 264003;Expression and significance of RUNX3 and CD44v6 in non-small-cell lung cancer[J];Journal of Binzhou Medical University;2011-01
7 XIONG Zheng-wen,ZHU Guang-ju,SU Hong,et al.Department of Pathology,the 25th Hospital of PAL,Zhang Jiakou,075000,China.;Study of the Expression of CD44s Gene Protein in Non-small Cellular Lung Cancer[J];Journal of Chinese Physician;2002-S1
8 JIANG Wu-zhong,LIANG Shao-qiang, LU Jing-cheng, et al. Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China;Expression and Clinical Significance of nm23-H_1 Protein in Nasopharyngeal Carcinoma[J];Journal of Chinese Physician;2005-04
9 MEI Tong-hua 1, LI Chang-yi 1, HUANG Ai-long 2 ( 1Department of Respiratory Diseases, The Second Affiliated Hospital, 2Institute of Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010,China);Loss of heterozigosity of nm23-H_1 gene might induce lymph node metastasis in no-small-cell lung cancer[J];Acta Academiae Medicinae Militaris Tertiae;2005-12
10 CAO Yun Xin 1, LIU Zhi Guang 1, ZHANG Xiao Nan 1, DONG Ju Ying 2 1Central Laboratory, 2Department of Biochemistry, Fourth Military Medical University, Xi’an 710033, China;Indirect staining of peripheral blood samples for flow cytometry[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LIU Guang-min1,2, JIA Xiao-bin1,2, WANG Heng-bin3, FENG Liang1, CHEN Yan1, GAO Cheng-lin1 (1Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China; 2Department of Pharmaceutics, Jiangsu University, Zhenjiang 212013, China; 3Changshu Leiyunshang Pharmaceutical Co.,LTD, Changshu 215500, China);Research development of molecular action target of Chinese materia medica in preventing and treating lung cancer[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-08
2 JIN Yang,TAO Xiaonan,SU Yuan,et al.Department of Pulmonary Medicine,Union Hospital of Tongji Medical College,Huazhong Science and Technology University,Wuhan 430022,China;The level of serum VEGF in patients with non-small cell lung cancer and relationship with the clinical[J];Journal of Clinical Internal Medicine;2006-09
3 ZHANG Lin, MENG Long, PENG Zhong-min, WANG Lei, DU Jia-jun, WANG Xiao-hang, CHEN Jing-han Department of Minimal Invasive Thoracic Surgery & Lung Transplantation Center, Shandong Provincial Hospital, Jinan 250021, P.R.China;Study on correlation of expression of VEGF mRNA and micrometastasis in peripheral blood in lung adenocarcinoma[J];Journal of Qilu Oncology;2005-19
4 ZHANG Lin,MENG Long,WANG Lei,et al;Expression of CD44V6 and matrix metalloproteinase-2 innon-small cell lung cancer[J];Shandong Medical Journal;2005-27
5 Jin Yang,Gao Yan,Su Yuan et alDepartment of Pulmonary Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022;Levels of Serum VEGF and MMP-9 in Patients with Non-small Cell Lung Cancer[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2006-03
6 ZHANG Wei-bin,LIANG Zhao-hui,HU Shao-wei,et al.(Traditional Chinese Medicine Hospital of Guangdong Province,Guangzhou 510120,China);EFFECT OF TRADITIONAL CHINESE MEDICINE COMPOUND ON PROLIFERATION AND METASTASIS OF LUNG CANCER CELL[J];Modern Preventive Medicine;2009-12
7 Hou Zhen-jiang,Zhang Zong-ying.(Cangzhou Medical College in Hebei,Cangzhou 061001,China);Advancement of Gene Detection In Ovarian Carcinoma Research[J];Medical Recapitulate;2006-07
8 PANG Shu-zhen,GUAN Jian-min,WANG Xu,WU Ai-hua,WANG Zhong-ying,LIU Ying (Heze Medical College,Heze 274030,Shandong,China);The Experimental Study of SXG Influences on the Expression of E-cadherin CD44V6 and nm23-H1 in Lewis Lung Cancer Metastatic Process[J];Chinese Archives of Traditional Chinese Medicine;2008-10
9 XIANG Zhi-ming 1*, XU Xiang-dong1, TAN Li-lian2 , HU Yu-sheng3, ZHOU Yan-fa3, ZHAO Shi-yu4(1.MR Room of Panyu People's Hospital, Guangzhou 511400, China; 2.Department of Radiology, the Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China; 3.Department of Radiology, 4.Room of Immunohistochemistry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China);Correlation between MRI appearance and expression of CD44v6 in peripheral lung cancer[J];Chinese Journal of Medical Imaging Technology;2006-04
10 REN Wei-min,ZHANG Pei-tong (Guang'anmen Hospital,Chinese Academy of Traditional Medical Sciences,Beijing 100053,China);An Overview on Molecular Mechanism of Blood Stasis Syndrome and Blood Activating Drug on Tumor Metastasis[J];China Cancer;2011-07
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