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《Chinese Journal of Lung Cancer》 2002-06
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The prognostic significance of GLUT1 expression in stage Ⅰ and Ⅱ NSCLC

WANG Kun , SUN Yu'e, WANG Tao. Department of Thoracic Surgery, General Hospital of Beijing Unit, PLA, Beijing 100700, P.R.China  
Objective To study the correlation between the intensity of facilitative glucose transporter(GLUT1) expression and prognosis in stage Ⅰ and Ⅱ non small cell lung cancer (NSCLC). Methods Eighty seven specimens were immunohistochemically stained using an antibody against GLUT1 antigen, and the intensity of GLUT1 expression was assessed by computer image analysis system in NSCLC with pathologic stage Ⅰ and Ⅱ. Results Eighty one cases of NSCLC (93.1%) were GLUT1 positive. The intensity of GLUT1 expression (optic density) was significantly higher in lymph node metastasis positive group than that in negative group ( 0.340 7 ±0.070 3 vs 0.276 5±0.082 4, P0.05). The patients with high GLUT1 expression ( 0.298 1 ) had significantly lower survival time than those with low GLUT1 expression (≤ 0.298 1 )(P 0.05 ). Conclusion GLUT1 is closely correlated with the prognosis of NSCLC patients in stage Ⅰ and Ⅱ.
【CateGory Index】: R734.2
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Kun *, SUN Yu'e, WANG Tao. *Department of Thoracic Surgery, General Hospital of Beijing Unit,PLA, Beijing 100700, P.R.China;Expression of GLUT1 protein and its relationship with uptake of FDG in non-small cell lung cancer tissues[J];Chinese Journal of Lung Cancer;2002-03
【Co-citations】
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【Secondary Citations】
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