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《Chinese Journal of Lung Cancer》 2003-05
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A randomized clinical trial on adjuvant interferon-alpha for completely resected stage Ⅰ--Ⅱ non-small cell lung cancer

YANG Xuening , WU Yilong, WANG Siyu, HUANG Zhifan, OU Wei, YU Hui. Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, P.R.China  
Objective To investigate the role of interferon alpha (IFN α) in completely resected stage Ⅰ and Ⅱ non small cell lung cancer (NSCLC) patients. Methods Forty four stageⅠand Ⅱ NSCLC patients were randomized to two groups. Study group (surgery+IFN α) received IFN α injection, 3 million unit, every two days, with a period of treatment of 90 days. Control group (surgery only) received no adjuvant therapy until relapse or metastasis were detected. pTNM stage, histological types, relapse or metastasis, survival time were observed and evaluated. Results Median follow up was 49.9 months. The 1 , 2 , 3 , 4 year survival rates were 90.5%, 80.9%, 52.4%, 52.4% in the study group and 95.2%, 80.9%, 66.0%, 50.8% in the control group respectively. No significant statistic difference was found between the two groups ( P = 0.663 9 ). Kaplan Meier and Cox Model analysis showed pTNM stage ( P =0.010 2), N status ( P =0.015) and weight loss ( P =0.030) were prognostic factors in completely resected stage Ⅰ and Ⅱ NSCLC. Conclusion Postoperative low dose IFN α short term therapy cannot significantly improve 3 and 4 year survival rates of patients with stage Ⅰ and Ⅱ completely resected NSCLC.
【Fund】: 卫生部科学研究基金 (98 2 377)资助~~
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 WANG Meng,WANG Chang-Li. Department of Thoracic Surgery,Cancer Hospital,Tianjin Medical University,Tianjin,300060;The Comparison of the Effect of Adjuvant Chemotherapy and Interferon on Survival after Complete Resection of Non-small-cell Lung Cancer(stageⅠ)[J];The Practical Journal of Cancer;2007-03
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIAO Mei-lin (Shanghai Chest Hospital,Shanghai 200030,China);The Applications of Bio-therapy and Chemotherapy in the Multi-modality Treatment of NSCLC[J];Bulletin of Chinese Cancer;2001-12
2 WU Yilong, HUANG Zhifan, RONG Tiehua, et al. Tumor Hospital, Cancer Center, Sun Yet sen University of Medical Sciences, Guangzhou 510060;Post operative staging and survival based on the revised TNM staging system for non small cell lung cancer[J];CHINESE JOURNAL OF ONCOLOGY;1999-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wang Wei 1 ,Rong Tie-Hua 2 ,Zhang Li 1 ,Jiang Wen-Qi 1 ,Xu Guang -Chuan 1 ,Huang Hui-Qiang 1 ,He You-Jian 1 ,Guan Zhong -Zhen 1 Department of Medical Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China2.Department of Thoracic Surgery,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China;Multivariate Survival Analysis for 423 Patients with Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2003-06
2 LIN Zhi-Chao1,2,3, LONG Hao1,2,3, RONG Tie-Hua1,2,3, YANG Ming-Tian1,2,3, HUANG Zhi-Fan1,2,3, LIN Peng1,2,3, ZHANG Lan-Jun1,2,3, LI Xiao-Dong1,2,3 1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 3. Lung Cancer Research Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Surgical Treatment Efficacy of Bronchioloalveolar Carcinoma:A Retrospective Analysis of 130 Patients[J];Chinese Journal of Cancer;2006-09
3 WEI Wei-Dong1,2,WEN Zhe-Sheng1,2,SU Xiao-Dong1,2,LIN Peng1,2,RONG Tie-Hua1,2,CHEN Li-Kun1,3 1. Stake Key Laboratory of Oncology in South China,Guangzhou,Guangdong,510060,P. R. China 2. Department of Thoracic Surgery,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P. R. China 3. Department of Medical Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P. R. China;Multivariate Survival Analysis of 899 Patients with Non-small Cell Lung Cancer after Complete Resection[J];Chinese Journal of Cancer;2007-11
4 ;Progress in Multi-modality Treatment of Lung Cancer[J];China Comtemporary Medicine;2001-06
5 GONG Tai-qian, JIANG Yao-guang, WANG Ru-wen, FAN Shi-zhi, ZHOU Jing-hai, ZHAO Yun-ping, TAN Qun-you, MA Zheng, LIN Yi-dan (Thoracic and Cardiovascular Surgery Research Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Changes of pulmonary functions after pneumonectomy[J];Acta Academiae Medicinae Militaris Tertiae;2005-07
6 WANG Siyu, WU Yilong, OU Wei, YANG Xuening, Y U Hui. Lung Cancer Research Center, Sun Yet sen University of Medical Sciences , Guangzhou, Guangdong 510060, P.R.China;Survival and prognosis after pneumonectomy for non small cell lung canc er (NSCLC) in the elderly[J];CHINESE JOURNAL OF LUNG CANCER;2000-03
7 ZHANG Xun, ZHAO Fuyuan, ZHANG Lianxiang, ZHAO Hui, WANG Xueqin, CAI Zhong, ZHENG Cuiying, TIAN Tieshuan, LU Xike, WANG Kuojian. Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300051, P.R.China;Research on cellular immune function of patients with lung cancer before and after operation[J];Chinese Journal of Lung Cancer;2003-04
8 ZHANG Zhiyong, GUO Feng, CUI Yushang, LI Shanqing, LI Li, XU Xiaohui, GE Feng, GUO Huiqin, LI Zejian. Department of Thoracic Surgery, PUMC Hospital, Beijing 100730, P.R.China;The study on improvement of survival for lung cancer surgically intervened in PUMC Hospital[J];Chinese Journal of Lung Cancer;2005-02
9 ZHANG Binbin, WANG Siyu, QU Wei, LIN Yongbin, YANG Hua, SUN Haibo Thoracic Department, Cancer Center of Sun Yat-sen University, GuangzhouGuangdong 510060, China;Clinical verification of a mathematical model for prediction of brain metastases in patients with locally advanced non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2008-03
10 Yongbin LIN 1,3,4, Ying LIANG 2,3,4, Peng LIN 1,3,4, Zhihua ZHU 1,3,4, Xu ZHANG 1,3,4, Jianhua FU 1,3,4, Lanjun ZHANG 1,3,4, Hao LONG 1,3,4, Siyu WANG 1,3,4, Canguang ZENG 1,3,4, Tiehua RONG 1,3,41 Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China; 2 Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China; 3 State Key laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, China; 4 Lung Cancer Research Center, Cancer Center, Sun Yat-sen University, Guangzhou,, 510060, China;Survival and Progostic Factors in Resected IIIA-N2 Non-small Cell Lung Cancer:A Study of 288 Cases[J];Chinese Journal of Lung Cancer;2009-06
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Zhao Jun, Zhang Lihua, Zhou Yufang, Si Haiyun (Department of Oncology, Liaocheng People's Hospital, Liaocheng 252000, China);A Clinical Study on the Double Pathway for Advanced Non-small-cell Lung Cancer[J];Henan Journal of Oncology;2004-02
2 LIAO Mei-lin (Shanghai Chest Hospital,Shanghai 200030,China);The Applications of Bio-therapy and Chemotherapy in the Multi-modality Treatment of NSCLC[J];Bulletin of Chinese Cancer;2001-12
3 Shi Qingming, Zhang Yiiven ( Pulmonary Hospital of Anhui Province , Hefei, 250022);The Therapeutic Effect of Short Term Administration of IFN-α on Non-Small Cell Lung Carcinoma[J];Chinese Journal of Cancer Biotherapy;1997-02
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Xu Lin,Zhon Xinguan,Wang Jun,et al(Jiangsu Cancer Hospital,Nanjing,210009);Detection on the Seurm Levels of sIL 2R in Non small Cell Lung Cancer[J];THE PRACTICAL JOURNAL OF CANCER;1997-01
2 ZHU Xiaosong; HU Hongzao; LI Liming(Department of Thoracic Surgery, Beijing Jiu Xian Qiao Hospital, Beijing 100016);An immuno-suppressive factor in the serum of patients with lung cancer[J];CHINESE JOURNAL OF EXPERIMENTAL SURGERY;1999-03
3 LU Shun, LIAO Meilin, LIN Zhenqiong, et al. Research Laboratory of Clinical Oncology, Shanghai Chest Hospital, Shanghai 200030;A comparative study between clinical response and pathologic changes to preoperative chemotherapy in non small cell lung cancer[J];CHINESE JOURNAL OF ONCOLOGY;1999-05
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