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《Chinese Journal of Lung Cancer》 2004-02
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Combined chemotherapy of weekly paclitaxel and ifosfamide in the treatment of 23 patients with advanced non-small cell lung cancer

XU Hongxia , NIE Chunlan, HONG Zhuan. Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, Jiangsu 210009, P.R.China  
Objective To evaluate the efficacy and safety of weekly paclitaxel and ifosfamide in the treatment of advanced non-small cell lung cancer. Methods Twenty-three patients with advanced non-small cell lung cancer received paclitaxel 50--65 mg/m 2 IV weekly on days 1, 8, 15, and IFO 1.3 g/m 2 IV on days 2--4. The schedule was repeated every 28 days for two or three cycles as a course. Results One patient had complete response and eight had partial response. Eleven patients had stable disease and three had progressive disease. The overall response rate was 39.1%. Twenty patients were followed-up. The 1-year survival was 40%(8/20) and the median survival duration was 8.9 months. The main toxicities were hematological toxicity (leukopenia, 69.6%, 16/23) and nausea/vomiting (47.8%, 11/23). Conclusion Combined chemotherapy of weekly paclitaxel and ifosfamide is a good regimen for advanced non-small cell lung cancer with good efficacy and well-tolerated side effects.
【CateGory Index】: R734.2
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【References】
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1 LAO Yi CHEN Shao-feng LEI Gui-hua XU De-ming WANG Wei ZHONG HAI-ming Department of Oncology,The Central Hospital of Guangdong Province Agricultural Reclamation,Zhanjiang,Cuangdong 524002,China;Ifosfamide and vinorelbine combined chemotherapy in the treatment of advanced non-small cell lung cancer[J];Chinese Journal of Primary Medicine and Pharmacy;2006-08
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1 QU Fenglian, WANG Bin, HU Xingsheng. Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, P.R.China;Domestic paclitaxel-based regimens in the treatment of 31 patients with advanced lung cancer[J];Chinese Journal of Lung Cancer;2002-06
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