Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Lung Cancer》 2004-04
Add to Favorite Get Latest Update

Phase Ⅱ clinical trial of homemade human rh-endostatin in the treatment of patients with stage ⅢB--Ⅳ non-small cell lung cancer

SHI Heling, XU Liyan, LIU Zhe. Department of Medical Oncology, Beijing Tuberculosis and Thoracic Tumor Hospital, Beijing 101149, P.R.China  
Objective To evaluate the efficacy and safety of homemade human rh endostatin (YH 16) combined with NP regimen (vinorelbine+cisplatin) for stage ⅢB Ⅳ non small cell lung cancer (NSCLC), and to compare with NP regimen alone. Methods Eighteen NSCLC patients were divided into two groups. Group A ( n =9) received YH 16 combined with NP plan. Group B ( n =9) received NP regimen. They were treated with 2 or 3 cycles of chemotherapy. The overall response, time to progression (TTP), quality of life (QOL) and safety were observed. Results The overall response was 22.2% in group A, and 0% in group B ( P 0.05). The clinical benefit rate was 100% in group A, and 44.4% in group B ( P 0.05). There was no significant relationship between response and clinical pathological characteristics of patients ( P 0.05). The TTP was 178.8±70.8 days in group A and 85.4±48.2 days in group B ( P 0.05). The main toxicities of the two groups were hematological toxicities, nausea and vomiting. No significant difference in incidence of toxicity was observed between the two groups ( P 0.05). Conclusion The rh endostatin combined with NP regimen for NSCLC tends to show a better chemotherapeutic effect and less toxicity than NP regimen alone. It is worthy of extensive clinical trial.
【CateGory Index】: R734.205
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 WANG Qiang,PATIGULI Aerxidin,ZHANG Yan(First division of Internal Medicine,The Affiliated Xinjiang Tumor Hospital,Xinjiang Medical University,Urumchi 830011,China);Clinical observations of Endostar combine with chemotherapy injection on advanced non-small cell lung cancer[J];Journal of Chengdu Medical College;2010-04
2 Wenjing MENG, Qi GAO, Liuchun WANG, Chun HUANG, Kai LIDepartment of Pulmonary Oncology, Tianjin Medical University Tumor Institute and Hospital, Tianjin Lung Cancer Diagnosis and Treatment Centre, Tianjin 300060, China;Analysis of Cardiovascular-related Adverse Effects of Endostar Combined with Chemotherapy in 61 NSCLC Cases[J];Chinese Journal of Lung Cancer;2009-06
3 QIN Hai-feng,GAO Hong-jun(Internal Medicine Department of Pulmonary Neoplasm,Hospital No 307 of PLA,Beijing 100071,China);Advances in research on recombinant human endostatin(Endostar TM) in the treatment of non-small cell lung cancer[J];Military Medical Sciences;2011-07
4 DUAN Hao-qing,WANG Yuan-dong,ZHOU Ming.Department of Thoracic Surgery,Tumor Hospital,Affiliated to Guangzhou Medical College,Guangzhou 510095,China;Clinical observation of endostar combined with pemetrexed for advanced non-small cell lung cancer[J];Chinese Clinical Oncology;2010-02
5 Qingwei Zhou,Peng Du,Yue Qian,Qian Zhang,Baoshan Feng,Hongzhen Ding,Renbao Gan,and Hui Zhang Shanghai Apeloa Pharmaceutical Research Institute,Shanghai 201314,China;Endothelial genesis inhibitor-8t(EDI-8t) against tumor growth[J];Chinese Journal of Biotechnology;2010-12
6 WEN Feng,WANG Wei,SHANG Li-qun,LI Xue-chang,LI Jun,LIU Jun-Jiang(PLA Navy General Hospital,Beijing,100048);Observation of short term effects of endostar combined with NP regimen for Non-Small Cell Lung Cancer[J];Journal of Clinical Medicine in Practice;2011-13
7 ;Clinical effects and adverse reactions of recombinant human endostatin[J];Adverse Drug Reactions Journal;2007-01
8 ZHANG Qi,XIA Ai-jun(Department of pharmacy,303 hospital of PLA,Nanning 530021,China);Meta-analysis of combining rh-endostatin with chemotherapy in treatment of NSCLC[J];Journal of Pharmaceutical Practice;2010-06
9 CHEN Yu1,GE Wei1,YUAN Li2(1Department of Oncology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060;2Hubei University of Medicine,Shiyan,Hubei 442000,China);A Meta-analysis of Third-generation Chemotherapy Regimen Combined Endostatin on Treatment of Advanced Non-small-Cell Lung Cancer[J];Journal of Hubei University of Medicine;2011-02
10 LIU Yong-yu;Phase Ⅲ Clinical Trial of Recombinant Human Endostatin in the Treatment for Advanced Non-small Cell Lung Cancer Patients[J];Bulletin of Chinese Cancer;2005-06
China Proceedings of conference Full-text Database 2 Hits
1 PAN Yan (Department of Pharmacy,Shanghai Chest Hospital,200030);Development in clinical research of Endostar for malignant tumor[A];[C];2009
2 PAN Yan (Department of Pharmacy,Shanghai Chest Hospital,200030);Development in clinical research of Endostar for malignant tumor[A];[C];2010
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Su Lihong Zhou Ling Zhu Yan Li Fengqin (Institute of Materia,Shandong Academy of Medical Sciences,Jinan 250062);Recombinant Human Vascular Endostatin Inhibits Growth of Tumors in Nude Mice[J];Shandong Journal of Biomedical Engineering;2002-02
2 LIU Jiang-qiu, LI Zhong-yi, CHEN Lin-sheng, SUN Yi-hong, XU Lu, WANG Jun-yuan, LIU Wan-xing, XIA Jie-lai (Military Medical Institute of Shenyang Military Rigion, Shenyang 110034, Liaoning Province; Liaoning Research Institute of Satellite Biologicals; Ans;An experimental study on inhibiting growth and metastasis or mouse melanoma by engineering endostatin[J];Journal of Cellular and Molecular Immunology;2001-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 MA Wei-Lie,LIU Fang,HE Cheng-Wei,HE Zhen-HuiDepartment of Biochemistry,Guangdong Medical College,Zhanjiang 524023,China;Purification of mouse endostatin in thio-redoxin fusion expression system and identification of its biological activity[J];Journal of the Fourth Military Medical University;2006-05
2 Du HE1,Wei GE1,Changhu LI1,Zhenyu ZHAO1,Ximin XU1,Fang YANG2 1Department of Medical Oncology,Remmin Hospital of Wuhan University,Wuhan 430060,China;2College of Base Medicine,Wuhan University,Wuhan 430071,China;Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer[J];Chinese Journal of Lung Cancer;2010-04
3 Ling Lei,Liu Jiangqiu,Zhu Xiaohong,et al.Department of Pharmacy,202 Hospital of PLA,Shenyang 110003,China;Long-term toxicity of endostatin injection to Beagle dogs[J];Medical Journal of Chinese People's Liberation Army;2007-06
4 QIN Shu-kui,LIU Xiu-feng,WANG Lin,CHEN Ying-xia,QIAN Jun,HUA Hai-qing,GONG Xin-lei,YANG Liu-qing,HE Ze-ming.Department of Medical Oncology,PLA Cancer Center,81 Hospital of PLA,Nanjing 210002,China;Clinical study of endostar combined with chemotherapy for the multiple kind of advanced malignancies except lung cancer[J];Chinese Clinical Oncology;2007-10
5 WU Shang-min1,ZHAO Ya-nan1,YANG Li2,WANG Lu2,GUO Shu-zhong2,LIU Yin1,LIU Dan2,LU Kai-hua2(1.Department of Plastic Surgery,Second Afiliated Hospital,Kunming Medical College,Kunming 650101,Yunnan,China.2.The Centre of Plastic Surgery,the Fourth Military Medical University,Xi'an 710032,Shaanxi,China);Effects of recombinanted human angiostatin on vascular endothelial cell[J];Chinese Journal of Aesthetic Medicine;2008-05
6 WANG Cheng-wei1,ZHU Can-hong1,SHU Yong-qian2(1.The Affiliated People′s Hospital of Jiangsu University,Zhenjiang,212002; 2.The First Affiliated Hospital of Nanjing Medical University,Nanjing,210029);Synergistic Inhibitory Effects of Endostatin and Radiation Therapy on Angiogenesis of Lewis Lung Cancer in Nude Mice[J];Journal of Clinical Medicine in Practice;2007-03
7 JING Xia1,GUO Qing-long2(1.Nanjing Children′s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China;2.Key Laboratory of Carcinogenesis and Intervention of Jiangsu Province,China Pharmaceutical University,Nanjing 210009,China);The Functions of Matrikines in the Progress of Tumor Angiogenesis and the Development of Related Drugs[J];Progress in Pharmaceutical Sciences;2009-02
8 Wang Dong Zhong Zhao-yang Li Zengpeng et al Cancer Center and Department of Pathology,Daping Hospital,the Third Military Medical University,Chongqing;Effects of Endostatin Treatment on Human Osteosarcoma Xenografts in Nude Mice[J];Chinese Journal of Clinical Oncology;2007-01
9 LI Zhong-yi, WANG Jun-yuan, LIU Jiang-qiu, CHEN Lin-sheng , LI Ning ( Military Medical Institute of Shenyang Military Rigion, Shenyang 110034, China; Liaoning Tumor Biological Gene-Therapy Center);Expression and Purification of Recombinant Human Endostatin[J];Chinese Journal of Cancer Biotherapy;2002-02
10 WANG Tian-bao 1, WU Xiao-peng 2, ZHANG Wei-dong 3, LI Zhao-ting 2 (1.Department of Gastrointestinopancreatic Surgery,The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080,China;2. Department of General Surgery, Qilu Hospital,Shandong University,Jinan 250012,China;3. Department of Pathology,Academy of Medical Sciences of Shandong Province,Jinan 250012, China);The influences of recombinant human endostatin on the growth of gastric cancer in nude mices[J];Chinese Journal of General Surgery;2004-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Guo feng*, WANG Yuan he, ZHANG Ming ao, WANG Qiang, LUO Yun bao, WANG Deng shan, Han Ce ran Department of General Surgery, Changzheng Hospital,Second Military Medical University, Shanghai 200003, P.R.China;Inhibition of Growth and Metastases of Human Colon Cancer Xenograft in Nude Mice by Angiogenesis Inhibitor Endostatin[J];Chinese Journal of Cancer;2002-01
2 ZHOU Zhi-Wei1,2, WAN De-Sen1,2, WANG Guo-Qiang1,2, REN Jing-Qing1,2, LU Zhen-Hai1,2, LIN Su-Xia1,3, TANG Shao-Xian1,2, YE Yan-Li1,4, CHEN Gong1,2 1. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong Province, 510060, P. R. China 2. Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong Province, 510060, P. R. China 3. Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong Province, 510060, P. R. China 4. Animal Experimental Center, Sun Yat-sen University, Guangzhou, Guangdong Province, 510060, P. R. China;Inhibitory Effect of Angiogenesis Inhibitor YH-16 on Liver Metastases from Colorectal Cancer[J];Chinese Journal of Cancer;2006-07
3 CAO Kajia,MAO Zhida, CUI Nianji, et al Department of Radiotherapy, Cancer Center, Sun Yatsen University of Medical Sciences, Guangzhoun 510060, China;Influence of radiotherapy on the effectiveness of chemotherapy in patients with limited and extensive stages of small cell lung cancer (SCLC)[J];CHINESE JOURNAL OF CANCER;1999-03
4 Yan Shilin Li Weihong Gao Feng Lin Chenqing (The University of Tradional Chinese Medicine of Chengdu, Chengdu 610075, China);The research of cold and heat syndrome about advanced primary branchogenic carcinoma[J];Oncology Progress;2004-02
5 Li Jinhan Dept.of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;The treatment of non-small cell lung cancer with integrated traditional Chinese medicine and Western medicine:Improving survival[J];Oncology Progress;2006-06
6 Chen Zhendong Bu Lijia Wu Xuwei Du Yingying Department of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Dermatological toxicities to EGFR inhibitors:Diagnosis and management[J];Oncology Progress;2007-06
7 Yuan Xia~1 Zhang Dongsheng~1 Yuan Zhongyu~1 He Ying~2 Ma Huimin~2 Li Jun~2 Jiang Wenqi~(1#) 1 State Key Laboratory of Oncology in South China,Department of Medical Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China 2 Huizhou Municipal Center Hospital,Huizhou,Guangdnng,516001,P.R.China;Endostar combined with chemotherapy in the treatment of HER-2 negative breast cancer[J];Oncology Progress;2007-06
8 HUANG Zhu-hua,PU Chun-hua,ZHOU Zheng-guang,XIE Guang-long,LIU Xin-qun,YE Hong,LIN Nan (Department of Medical Oncology,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China);Ultra sound-guided aspiration biopsy in diagnosis of peripheral lung cancer[J];Journal of Bengbu Medical College;2006-04
9 WEI Biao~1 JIANG Wen-jun~2 TANG Xiao-lan~2 (1.The Second People's Hospital of Yibin,Sichuan Yibin 644000;2.Cancer Hospital of Sichuan Province,Chengdu 610041,China);The Clinical Study on the Therapeutics of Cytokine-induced Killer Cells on the Patients with Advanced Non-small-cell Lung Cancer[J];Journal of Chengdu Medical College;2008-03
10 MA Ling-Yun,LI Qiang * ,LIU Zhong-Ling(Department of Respiratory Diseases,Changhai Hospital,Second Military Medical University,Shanghai200433,China);Combination of adenovirus-mediated endostatin gene and chemotherapy in treatment of Lewis lung cancer in mice[J];Academic Journal of Second Military Medical University;2004-07
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WANG Qiang,PATIGULI Aerxidin,ZHANG Yan(First division of Internal Medicine,The Affiliated Xinjiang Tumor Hospital,Xinjiang Medical University,Urumchi 830011,China);Clinical observations of Endostar combine with chemotherapy injection on advanced non-small cell lung cancer[J];Journal of Chengdu Medical College;2010-04
2 Wenjing MENG, Qi GAO, Liuchun WANG, Chun HUANG, Kai LIDepartment of Pulmonary Oncology, Tianjin Medical University Tumor Institute and Hospital, Tianjin Lung Cancer Diagnosis and Treatment Centre, Tianjin 300060, China;Analysis of Cardiovascular-related Adverse Effects of Endostar Combined with Chemotherapy in 61 NSCLC Cases[J];Chinese Journal of Lung Cancer;2009-06
3 Haiyu MU,Chunyan SHEN,Yiling FENG Cancer center,The affiliated hospitalof Armed Police for Medical College,Tianjin 300162,China;Clinical Observation on the Target Therapy of Rh-Endostin,Combined with Chemotherapy in Advanced Non-Small Cell Lung Cancer[J];Chinese Journal of Lung Cancer;2009-07
4 Dedong CAO,Wei GE,Huimin WANG,Ling ZHANG,Yongfa ZHENG,Jinzhong ZHANG Department of Medical Oncology,Remmin Hospital of Wuhan University,Wuhan 430060,China;Efficacy and Safety of rh-Endostatin Combined with Chemotherapy versus Chemotherapy Alone for Advanced NSCLC:A Meta-analysis Review[J];Chinese Journal of Lung Cancer;2011-05
5 LIU Liang,GE Wei,LUO Shun-xiang,et al.(Department of Medical Oncology,Ren Min Hospital of Wuhan University,Wuhan 430060,China);A Systematic Evaluation of Efficacy and Safety of Endostar Combined with Chemotherapy in Treating Advanced Non-small-cell Lung Cancer[J];Journal of Hubei University for Nationalities(Medical Edition);2012-01
6 PENG Da-yong,LI Jun,WEN Kang,ZHAO Wen-jing(Department of oncology,Shanghai Meishan Hospital of Nanjing,Nanjing,Jiangsu 210039,China);Clinical Effect of Recombinant Human Endostatin Combined with Routine Chemotherapy on Postoperative Adjuvant Chemotherapy for Non-Small-Cell Lung Cancer[J];Journal of Chengdu Medical College;2012-02
7 Liao Ya-yong,Ning Bing-you,Long Guang-feng,et al.(Department of Oncology,The People's Hospital of Jiangmen,Guangdong Province,Jiangmen 529000,China);Clinical Observation of Recombinant Human Endostatin Combined with Transcatheter Arterial Chemoembolization for the Treatment of Massive Hepatocarcinoma[J];Chinese Journal of Medicinal Guide;2012-11
8 Wang Aimin;Han Chunquan;Department of Oncology,No.175 Hospital of PLA,Southeast Hospital Affiliated to Xiamen University;;Recombinant human endostatin combined with FOLFIRI inhibits colorectal cancer in mice[J];Journal of Third Military Medical University;2013-21
9 Gu Hongbing,Zhu Yafang,Tan Qinghe,Lu Junguo(Department of Chemotherapy,Nantong Tumor Hospital,Nantong 226361,China);The Clinical Observation of Advanced NSCLC Treated by Recombinant Human Endostatin in Combination with NP Regimen[J];Journal of Basic and Clinical Oncology;2010-01
10 GENG Li,WANG Rui The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Clinical observation of endostar combined with Alimta chemotherapy as the second line for advanced stage NSCLC[J];Journal of Medical Forum;2011-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved