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《Chinese Journal of Lung Cancer》 2008-02
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Effect of quercetin on the expression and growth of caspase-3 in lung adenocarcinoma cancer cell line A549

WEN Chunsheng,YING Binwu,ZHANG Yonggang,ZHANG Jie,FAN Hong Department of Respiratory Medicine,Department of Laboratory Medicine,West China Hospital,Sichuan University, Chengdu,Sichuan 610041,China. Corresponding author:fanhongfan@yahoo.com  
Background and objective To study the influence of Quercetin in the expression of caspase-3 in Lung Adenocarcinoma Cancer cell line A549.Methods The mRNA expression of caspase-3 in A549 Cells was detected by RT-PCR ,and the protein expression was detected by Western blot.Results The mRNA and protein expressions of caspase-3 was enhanced by Quercetin in dose-and time-dependent manners.Conclusion The enhancement effects of Quercetin on caspase-3 in A549 cells may provide promising therapy of tumor.
【Fund】: 国家自然科学基金(No.30470761);; 中国博士后科学基金(No.2005038268)资助~~
【CateGory Index】: R734.2
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