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《Chinese Journal of Lung Cancer》 2009-07
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Clinical Observation on the Target Therapy of Rh-Endostin,Combined with Chemotherapy in Advanced Non-Small Cell Lung Cancer

Haiyu MU,Chunyan SHEN,Yiling FENG Cancer center,The affiliated hospitalof Armed Police for Medical College,Tianjin 300162,China  
Background and objective The chemotherapy of advanced non-small cell lung cancer is in a Bottleneck.The target therapy of Anti-angiogenesis gradually shows an advantage in the therapy of patients with advanced NSCLC.To investigate the short-term efficacy,safety and the quality of life of the target therapy of rh-Endostin combined with chemotherapy in patients with advanced NSCLC.Methods Sixty-two advanced NSCLC patients were randomly divided into either the trial group with chemotherapy plus rh-Endostin or control group with chemotherapy alone.The efficacy and toxicity were evaluated after 2 cycles according to RECIST criteria.Results The trial groups efficiency rate was 46.87%,while the control group was 26.66%,there was no significant differences of two groups(χ2=1.912,P=0.166).The clinical benefit rate was 81.25% in the trial group and 53.33% in control group.There was significant difference of the clinical benefit rate between the trial group and the control group(χ2=4.3185,P=0.0377).The score of quality of life in the trial group was significantly higher than that the control group after the treatment(χ2=11.233,P=0.0008).There was no significant difference of incidence of toxicities between the trial group and the control group(P0.05).Conclusion Rh-Endostin combined with chemotherapy was effective,reasonable,safe and well tolerated for advanced NSCLC.
【CateGory Index】: R734.2
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