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《Journal of Hubei Institute For Nationalities Medical Edition》 2002-04
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The Changes of Electrocardiogram and Cardiac ET -1, ANP and the Levels of Serum CK, CK -MB and cTnl in Early Phase of Crush in Jury Rats

LIU Shui - ping, CHEN Yu - chuan, GUO Wei, et al.( Department of Forensic Pathology, Sun Yat - sen University of Medical Sciences, Guangzhou, Guangdong, 510080, China)  
Objective To observe the changes of electrocardiogram and cardiac endothelin -1 (ET-1) , atrial natriuretic peptide(ANP) contents and the levels of serum CK, CK-MB and cardiac troponin I(cTnl) in crush injury rats. Methods Crush injury was produced in Sprague -Dawley rats. The changes of electrocardiogram were recorded with the standard I; The serum levels of CK, CK, MB and cardiac troponin I, the cardiac ET -1 and ANP contents were studied by automated biochemical analyzer, automated chemiluminescence assay and radioimmunoas-say respectively. Results The ST segment elevated and the heart rate decreased considerably after crush injury, the cardiac ET-1 and ANP contents were much lower and the levels of serum CK, CK -MB and cTnl were much higher than those of the control groupes. Conclusion Cardiomyocyte injury was induced and ET-1, ANP may play some role on it in the early phase of crush injury.
【CateGory Index】: R642
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 WEI Dan,WANG Yue,YUAN Jia-bin,et al.;Significance of renal replacement therapy in the limb salvage treatment of the crush syndrome patients of earthquake[J];Practical Journal of Clinical Medicine;2009-01
2 LIU Shui-ping 1, CHEN Yu-chuan 1, LIU Xiu-qin 2, GUO Wei 1, CHENG Jian-ding 1 (? 1?Department of Forensic Pathology,? 2?Department of Nuclear Medicine, Sun Yat-sen University of Medical Sciences,Guangzhou 510080,China);Pathogenesis of early cardiac myocyte damage after severe crush injury[J];Chinese Journal of Pathophysiology;2002-06
3 LIU Shuiping, CHEN Yuchuan, GUO Wei, et al. Department of Forensic Pathology, Sun Yat sen University of Medical Sciences, Guangzhou 510080, China;An experimental study of early cardiac myocyte damage after severe crush injury[J];Chinese Journal of Traumatology;2001-12
4 XU Wei-dong,ZHANG Chun-cai,LI Ming;Early management of earthquake crush injury[J];Orthopedic Journal of China;2008-20
5 LIU Shui ping, CHEN Yu chuan, GUO Wei, WANG Jiang feng, CHENG Jian ding. (Department of Forensic Pathology, Sun Yat sen University of Medical Sciences, Guangzhou 510080, China);The Relation Between the Contents of Plasma Endothelin and Heart Injury in Crush Injury Rats[J];Academic Journal of Sun Yat-sen University of Medical Sciences;2002-01
6 WANG Kun, ZHANG Kou-xin, YAN Ling, WAN Hui, LI Xi, LIN Nan, GUO Dong, WANG Gen-shu, CAI Dao-zhang ( Department of Earthquake Wounded Cure, The Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China );Strategy of Treating Limbs Open Injury in Earthquake[J];Journal of Sun Yat-Sen University(Medical Sciences);2008-05
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